서늘한 곳에 보관하십시오. 건조하고 통풍이 잘되는 곳에 단단히 밀폐하여 보관할 것. 개봉 한 용기는 조심스럽게 밀봉하고 누출을 방지하기 위해 똑바로 세워야합니다. 권장 보관 온도 2 - 8 ° C 습기에 민감 함.
화학적 성질
Colorless to light yellow liqui
물리적 성질
bp 57–59 °C/8 mmHg; d 0.942 g cm?3.
용도
2-(Trimethylsilyl)ethoxymethyl Chloride is a reagent used in the protection of alcohols, secondary aryl amines, and imidazole,
indole, and pyrrole nitrogens;electrophilic formaldehyde
equivalent; acyl anion equivalent,used in One-carbon Homologations, Cyclizations etc.
일반 설명
2-(Trimethylsilyl)ethoxymethyl chloride (SEM-Cl) is a widely used reagent for the preparation protection groups for amines, alcohols, phenols, and carboxy groups. The nitrogen of amides and sulfonamides groups are also protected by using SEM-Cl reagent.
Purification Methods
Dissolve SEMCl in pentane, dry it (MgSO4), evaporate and distil the residual oil in a vacuum. Stabilise it with 10ppm of diisopropylamine. Store it under N2 in a sealed container in a refrigerator. [Lipshutz & Pegram Tetrahedron Lett 21 3343 1980.]
