Goserelin acetate

Goserelin acetate 구조식 이미지
카스 번호:
145781-92-6
상품명:
Goserelin acetate
동의어(영문):
Fertilan;Goserelin HCl;Goserelin acetate;Gosorelin Acetate;Goserelin Acteate;Goserilyn acetate;ICI-118630 acetate;Goserelin acetate/Fertilan;Goserelin?Acetate impurity;Goserelin Acetate(acetate)
CBNumber:
CB1281026
분자식:
C61H88N18O16
포뮬러 무게:
1329.49
MOL 파일:
145781-92-6.mol
MSDS 파일:
SDS

Goserelin acetate 속성

녹는점
>190°C (dec.)
저장 조건
-20°C
용해도
H2O: 20 mg/mL, 투명, 무색
물리적 상태
백색분말
색상
흰색에서 황백색까지
안정성
흡습성
InChIKey
IKDXDQDKCZPQSZ-JHYYTBFNSA-N
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
안전지침서 22-24/25
WGK 독일 3
RTECS 번호 OK6369800
HS 번호 2937190000
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H360 태아 또는 생식능력에 손상을 일으킬 수 있음 생식독성 물질 구분 1A, 1B 위험 GHS hazard pictograms
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2 0

Goserelin acetate C화학적 특성, 용도, 생산

개요

Goserelin acetate, like leuprolide acetate, is a synthetic superagonist nonapeptide analogue of GnRH that possesses greater potency than the natural hormone. Note that it contains D-Ser(But) and NH-NHCONH2 in place of Gly6 and Gly10-NH2, respectively. That is, the C terminal modification simply has an NH substituting for the CH2 of Gly, and like the C-terminal change in leuprolide acetate, this inhibits enzymatic degradation of the peptide by the postproline carboxyamide peptidase.
Goserelin acetate is available in the form of a small, solid pellet that is administered as an SC implant for the palliative treatment of advanced, metastatic breast cancer in pre- and perimenopausal women or, similarly, as a palliative in advanced prostatic cancer. The rationale for this drug's use is, as described above, its ability as a superagonist to bring the levels of estradiol or testosterone to near castrate levels, thus slowing the progression of breast or prostate carcinoma, respectively. Additionally, goserelin acetate is approved for use in treating endometriosis for up to 6 months.

화학적 성질

White Solid

용도

Synthetic peptide agonist analog of LH-RH. Antineoplastic (hormonal).

일반 설명

Goserelin acetate is a synthetic decapaptide, which is a potent analog of LHRH (luteinizing hormone releasing hormone).

Clinical Use

Goserelin acetate also is used in combination with the antiandrogen flutamide for shrinking prostate carcinoma before radiation therapy. This maximal androgen blockade combination is used when the prostate carcinoma has been staged as locally confined to the prostate gland, with one or both lobes as well as the seminal vesicles involved. The treatment should start 8 weeks before radiation treatment begins and be continued throughout the radiation therapy.
Furthermore, women who are to undergo hysterectomy for menorrhagia can benefit from previous treatment with goserelin acetate, because it is able to induce endometrial thinning. This thinning of the endometrium improves the operating environment by causing less intrauterine bleeding, increased postoperative amenorrhea, and decreased dysmenorrhea following surgery, which is why goserelin acetate is approved for inducing endometrial thinning prior to a patient undergoing a hysterectomy for heavy menstrual bleeding.

Goserelin acetate 준비 용품 및 원자재

원자재

준비 용품


Goserelin acetate 공급 업체

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sales@chemdad.com China 39916 58

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