아니시딘
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아니시딘 속성
- 녹는점
- 3-6 °C(lit.)
- 끓는 점
- 225 °C(lit.)
- 밀도
- 1.092 g/mL at 25 °C(lit.)
- 증기압
- <0.1 at 25 °C (NIOSH, 1994)
- 굴절률
- n
20/D 1.574(lit.)
- 인화점
- 210 °F
- 저장 조건
- Refrigerator
- 용해도
- 14g/L
- 물리적 상태
- 분말/고체
- 산도 계수 (pKa)
- 4.52(at 25℃)
- 색상
- 회백색
- 수소이온지수(pH)
- 7.3 (1g/l, H2O, 20℃)
- 수용성
- 13g/L(20℃)
- 감도
- Light Sensitive
- Merck
- 14,667
- BRN
- 386210
- Henry's Law Constant
- 1.25 at 25 °C (approximate - calculated from water solubility and vapor pressure)
- 노출 한도
- Potential occupational carcinogen. NIOSH REL: TWA 0.5 mg/m3, IDLH 50 mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.1 ppm (adopted).
- Dielectric constant
- 5.2300000000000004
- 안정성
- 안정적인. 강산화제, 산무수물, 클로로포르메이트, 산, 일부 플라스틱, 고무와 호환되지 않습니다. 공기에 민감합니다.
- InChIKey
- VMPITZXILSNTON-UHFFFAOYSA-N
- LogP
- 1.180
- CAS 데이터베이스
- 90-04-0(CAS DataBase Reference)
- IARC
- 2A (Vol. Sup 7, 73, 127)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 45-23/24/25-68 | ||
안전지침서 | 53-45 | ||
유엔번호(UN No.) | UN 2431 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | BZ5410000 | ||
F 고인화성물질 | 8 | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29222200 | ||
유해 물질 데이터 | 90-04-0(Hazardous Substances Data) | ||
독성 | Acute oral LD50 for rats 2,000 mg/kg, wild birds 422 mg/kg, mice 1,400 mg/kg, rabbits 870 mg/kg (quoted, RTECS, 1985). | ||
IDLA | 50 mg/m3 | ||
기존화학 물질 | KE-23211 | ||
중점관리물질 필터링 | 별표1-36 |
아니시딘 C화학적 특성, 용도, 생산
개요
o-Anisidine was produced commercially in the United States from the 1920s until late 1950s. By 2009, worldwide only six industries manufactured o-anisidine, but none produced hydrochloride salt. o-Anisidine was available from 44 suppliers, including 20 US suppliers, and the hydrochloride salt was available from eight suppliers, including five US suppliers. US imports of o-anisidine and its hydrochloride salt are reported in the category ‘o-anisidines, p-anisidines, and p-phenetidine,’ and US exports are reported in the category ‘anisidines, dianisidines, phenetidines, and their salts.’ From 1989 to 2008, imports ranged from a high of over 4.6 million kg in 1996 to zero in 2007 and 2008, and exports ranged from zero to 262 000 kg. Reports filed under the US Environmental Protection Agency’s (EPA) Toxic Substances Control Act Inventory Up Rule indicated that United States production plus imports of o-anisidine totaled 500 000 lb–1 million lb in 1986, 1990, and 2006; 1 million–10 million lb in 1990 and 1998; and 10 000–500 000 lb in 2002.화학적 성질
Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors.o-Anisidine (or o-methoxyaniline) is an aromatic amine with a methoxyl group ortho to the amino group of aniline. It is a colorless to yellowish, pink, or reddish liquid.o-Anisidine is soluble in water and mineral oils, and miscible with alcohol, benzene, acetone, and diethylether. o-Anisidine hydrochloride, a salt of o-anisidine, is a grayish crystalline solid or powder at room temperature and is soluble in water (NTP, 2011).
물리적 성질
Colorless, yellow to reddish liquid with an amine-like odor. Becomes brown on exposure to air.용도
Similar to other aromatic amines, o-anisidine may cause methemglobinemia and cancer in humans. It is used mainly as an intermediate for the production of azo dyes and pigments. Other industrial uses of o-anisidine include synthesis of other dyes and pharmaceuticals, as a corrosion inhibitor for steel, and as an antioxidant for polymercaptan resins (IARC, 1999; HSDB, 2012).Intermediate for azo dyes and for guaiacol.
일반 설명
Clear, yellowish to reddish or brown liquid with an amine (fishy) odor.공기와 물의 반응
o-Anisidine darkens on exposure to air. Insoluble in water.반응 프로필
o-Anisidine is sensitive to heat. o-Anisidine is also sensitive to exposure to light. o-Anisidine is incompatible with strong oxidizers. o-Anisidine is also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. o-Anisidine will attack some forms of plastics, rubber and coatings. .위험도
Strong irritant. Toxic when absorbed through the skin. Possible carcinogen.건강위험
o-Anisidine was carcinogenic in experimental animals.화재위험
o-Anisidine is combustible.Safety Profile
Confirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.잠재적 노출
Anisidines are used in the manufacture of azo dyes; pharmaceuticals; textile-processing chemicals Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some coatings and some forms of plastic and rubber.Carcinogenicity
o-Anisidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental animals.환경귀착
Biological. o-Anisidine should be biodegradable according to OECD guidelines (Brown and Labouerer (1983). Chemical/Physical. At influent concentrations (pH 3.0) of 10, 1.0, 0.1, and 0.01 mg/L, the GAC adsorption capacities were 52, 20, 7.8, and 3.0 mg/g, respectively. At pHs 7 and 9, the GAC adsorption capacities were 110, 50, 23, and 10 mg/g at influent concentrations of 10, 1.0, 0.1, and 0.01 mg/L, respectively (Dobbs and Cohen, 1980).운송 방법
UN2431 Anisidines, Hazard Class: 6.1; Labels: 6.1-Poisonous materialsPurification Methods
It is separated from the m-and p-isomers by steam distillation. It is also separated from its usual synthetic precursor o-nitroanisole by dissolving it in dilute HCl (pH <2.0) extracting the nitro impurity with Et2O, adjusting the pH to ~8.0 with NaOH, extracting the amine into Et2O or steam distilling. Extract the distillate with Et2O, dry the extract (Na2SO4), filter, evaporate and fractionate the residual oil. Protect the almost colourless oil from light which turns it yellow in color. [Biggs & Robinson J Chem Soc 3881961, Nodzu et al. Yakugaku Zasshi (J Pharm Soc Japan) 71 713, 715 1951, Beilstein 13 IV 806.]폐기물 처리
Dissolve in combustible solvent (alcohols, benzene, etc.) and spray solution into furnace equipped with afterburner and scrubber, or burn spill residue on sand and soda ash absorbent in a furnace.아니시딘 준비 용품 및 원자재
원자재
준비 용품
2-Methoxybenzonitrile
NAPHTHOL AS-BI PHOSPHATE
Benzoic acid, 2-[[1-amino-7-[[4-[[6-amino-5-[(3-carboxy-4-hydroxyphenyl)azo]-1-hydroxy-3-sulfo-2-naphthalenyl]azo]-2-methoxyphenyl]azo]-8-hydroxy-3,6-disulfo-2-naphthalenyl]azo]-5-[[6-amino-5-[(3-carboxy-4-hydroxyphenyl)azo]-1-hydroxy-3-sul
METOXADIAZONE
N-(2-Methoxyphenyl)acetamide
3,8-DIMETHYL-1,10-PHENANTHROLINE
2-Methoxy-4-nitroaniline
나프톨 AS-올
4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER
1-(2-Methoxyphenyl)piperazine hydrobromide
N-(2-METHOXY-4-NITROPHENYL)ACETAMIDE
2-Methoxyphenyl isocyanate
FAST RED SALT ITR
Reactive Yellow KE-4RN
과이아콜
플루오르아니솔
3,4-DIHYDRO-8-HYDROXY-4-OXOQUINOLINE-3-CARBOXYLIC ACID
FAST RED B SALT
Fast Scarlet RC Base
SIRIUS YELLOW GC
2-METHOXYBENZENETHIOL
Disperse Orange 29
아세토아세트-오르토-톨루이디드
5-Chloro-2-methoxyaniline
N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE
Naphtanilide EL
4-HYDROXY-8-METHOXYQUINOLINE-3-CARBOXYLIC ACID
아세토초산 o-아니시다이드
크산투렌산
disodium 3,3'-[carbonylbis[imino(3-methoxy-4,1-phenylene)azo]]dibenzoate
바닐린
Fast Red ITR
5-BROMO-8-METHOXY-2-METHYL-QUINOLINE
1-(2-Methoxyphenyl)piperazine
4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
아니시딘 공급 업체
글로벌( 429)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12457 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |