3-메틸-1-페닐-2-피라졸린-5-온
|
|
3-메틸-1-페닐-2-피라졸린-5-온 속성
- 녹는점
- 126-128 °C(lit.)
- 끓는 점
- 287 °C265 mm Hg(lit.)
- 밀도
- 1,12 g/cm3
- 증기압
- 0.016Pa at 20℃
- 굴절률
- 1.6300 (estimate)
- 인화점
- 191°C/17mm
- 저장 조건
- 2-8°C
- 용해도
- 3.30g/L
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 2.73±0.50(Predicted)
- 색상
- 노란색에서 베이지색
- 수소이온지수(pH)
- 4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
- 수용성
- 3g/L(20℃)
- Merck
- 14,6713
- BRN
- 609575
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
- 주요 응용
- 펩타이드 합성
- 화장품 원료 기능
- 머리 염색
- InChI
- 1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
- InChIKey
- QELUYTUMUWHWMC-UHFFFAOYSA-N
- SMILES
- CC1=NN(C(=O)C1)c2ccccc2
- LogP
- 0.75 at 24℃
- CAS 데이터베이스
- 89-25-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 1 | ||
| RTECS 번호 | UQ9625000 | ||
| TSCA | TSCA listed | ||
| HS 번호 | 29331990 | ||
| 스토리지 클래스 | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
||
| 유해 물질 데이터 | 89-25-8(Hazardous Substances Data) | ||
| 독성 | LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79 | ||
| 기존화학 물질 | KE-10718 |
3-메틸-1-페닐-2-피라졸린-5-온 C화학적 특성, 용도, 생산
개요
Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.화학적 성질
Off white to light yellow powder용도
Edaravone inhibits the disease activity in rheumatoid arthritis.정의
ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.일반 설명
A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore.위험도
Toxic by ingestion.생물학적 활성
A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.Safety Profile
Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.Purification Methods
Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]3-메틸-1-페닐-2-피라졸린-5-온 준비 용품 및 원자재
원자재
아세틸 케텐
아질산 암모늄
아세토카민
암모니아수
에틸알코올
아세톡시아세트산
이아황산 암모늄, 고체
포르말린
개미산
아질산 나트륨
아닐린
염산
p-톨루이딘
메탄
황산
탄산나트륨(경회)
암모니아(가스)
산성아황산나트륨
디메틸설페이트
준비 용품
C.I. 산 노란색 17
sodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)]cobaltate(1-)
Neutral Bordeaux D-BN
Tracid Light Yellow G
Difenzoquat methylsulfate
Mordant Red 7
피라졸
3,5-디페닐피라졸
Cuprate(2-), [4-[bis[4-(diethylamino)phenyl]hydroxymethyl]-5-[(4,5-dihydro-3-methyl-5-(oxo-κO)-1-phenyl-1H-pyrazol-4-yl)azo-κN1]-6-(hydroxy-κO)-1,3-benzenedisulfonato(4-)]-, disodium
3-메틸-1-페닐-2-피라졸린-5-온 공급 업체
글로벌( 1046)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shandong Xinhua Pharmceutical Co.,LTD | 0533- 2196801 |
yaojianyong@xhzy.com | China | 70 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 |
anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Jiangsu Simcere Pharmaceutical CO.,Ltd | 025-85566666-7321 15195996671 |
API@simcere.com | China | 22 | 58 |
| Wuhan Blue Lotus Biotechnology Co | 13397278829 |
396628162@qq.com | China | 42 | 58 |
| Dao Kui Chemical (Shanghai) Co. LTD | 15995509766 |
296549925@qq.com | China | 140 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 |
market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 |
3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 |
sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 |
saleschina@alfa-asia.com | China | 30103 | 84 |