ChemicalBook >제품 카탈로그 >유기 화학>케톤>3-메틸-1-페닐-2-피라졸린-5-온

3-메틸-1-페닐-2-피라졸린-5-온

3-메틸-1-페닐-2-피라졸린-5-온 구조식 이미지

카스 번호:: 89-25-8

한글명:: 3-메틸-1-페닐-2-피라졸린-5-온

동의어(한글):: 3-메틸-1-페닐-2-피라졸린-5-온;3-메틸-1-페닐-5-피라졸론;3-메틸-1-페닐-5-피라졸론및그염류(예:페닐메틸피라졸론);페닐메틸피라졸론

상품명:: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

동의어(영문):: PMP;EDARAVONE;1-Phenyl-3-methyl-5-pyrazolone;5-METHYL-2-PHENYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONE;3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;Norphenazone;3-METHYL-1-PHENYL-5-PYRAZOLONE;3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE;MONOPYRAZOLONE;PHENYLMETHYLPYRAZOLON

CBNumber:: CB1287462

분자식:: C10H10N2O

포뮬러 무게:: 174.2

MOL 파일:: 89-25-8.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 865

3-메틸-1-페닐-2-피라졸린-5-온 속성

녹는점: 126-128 °C(lit.)

끓는 점: 287 °C265 mm Hg(lit.)

밀도: 1,12 g/cm³

증기압: 0.016Pa at 20℃

굴절률: 1.6300 (estimate)

인화점: 191°C/17mm

저장 조건: 2-8°C

용해도: 3.30g/L

산도 계수 (pKa): 2.73±0.50(Predicted)

물리적 상태: 결정성 분말

색상: 노란색에서 베이지색

수소이온지수(pH): 4.0-4.4 (H2O, 20℃)(saturated aqueous solution)

수용성: 3g/L(20℃)

Merck: 14,6713

BRN: 609575

안정성: 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N

LogP: 0.75 at 24℃

CAS 데이터베이스: 89-25-8(CAS DataBase Reference)

NIST: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)

EPA: 1-Phenyl-3-methyl-5-pyrazolone (89-25-8)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	1
RTECS 번호	UQ9625000
TSCA	Yes
HS 번호	29331990
유해 물질 데이터	89-25-8(Hazardous Substances Data)
독성	LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79
기존화학 물질	KE-10718

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

NFPA 704

	1
2		0

3-메틸-1-페닐-2-피라졸린-5-온 MSDS

Edaravone

3-메틸-1-페닐-2-피라졸린-5-온 C화학적 특성, 용도, 생산

개요

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

화학적 성질

Off white to light yellow powder

용도

Edaravone inhibits the disease activity in rheumatoid arthritis.

정의

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

일반 설명

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC₅₀ = 15 μM). Inhibits mitochondrial permeability transition pore.

위험도

Toxic by ingestion.

생물학적 활성

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

3-메틸-1-페닐-2-피라졸린-5-온 준비 용품 및 원자재

원자재

아세틸 케텐 아질산 암모늄 아세토카민 암모니아수 에틸알코올 Acetoxyacetic acid 이아황산 암모늄, 고체 포르말린 개미산 아질산 나트륨 아닐린 염산 p-톨루이딘 메탄 황산 탄산나트륨(경회) 암모니아(가스) 산성아황산나트륨 디메틸설페이트

준비 용품

C.I. 산 노란색 17 sodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)]cobaltate(1-) Neutral Bordeaux D-BN Tracid Light Yellow G DIFENZOQUAT METHYLSULFATE Mordant Red 7 피라졸 3,5-디페닐피라졸 Cuprate(2-), [4-[bis[4-(diethylamino)phenyl]hydroxymethyl]-5-[(4,5-dihydro-3-methyl-5-(oxo-κO)-1-phenyl-1H-pyrazol-4-yl)azo-κN1]-6-(hydroxy-κO)-1,3-benzenedisulfonato(4-)]-, disodium

3-메틸-1-페닐-2-피라졸린-5-온 공급 업체

글로벌( 865)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	mack@tongyon.com	China	2996	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7613	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	17791478691	yklbiotech@163.com	CHINA	296	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

3-메틸-1-페닐-2-피라졸린-5-온 관련 검색:

쿠레톡심메틸 메틸알콜 아크릴산메틸 메틸 바이올렛 (2B) 세프타졸린 나트륨 아세트산 메틸 아세토나이트릴 이염화파라콰트 메틸파라벤 디하이드로미르세놀 3-메틸-5-피라졸론 피라졸 3-메틸-1-페닐-2-피라졸린-5-온 BISPYRAZOLONE 4,5-dihydro-a-(hydroxyMethyl)-a,3-diMethyl-5-oxo-1-phenyl-1H-Pyrazole-4-Methanesulfonic acid 1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one Edaravone Glucuronide Edaravone N-Oxide