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3-메틸-1-페닐-2-피라졸린-5-온

3-메틸-1-페닐-2-피라졸린-5-온
3-메틸-1-페닐-2-피라졸린-5-온 구조식 이미지
카스 번호:
89-25-8
한글명:
3-메틸-1-페닐-2-피라졸린-5-온
동의어(한글):
3-메틸-1-페닐-2-피라졸린-5-온;3-메틸-1-페닐-5-피라졸론;3-메틸-1-페닐-5-피라졸론및그염류(예:페닐메틸피라졸론);페닐메틸피라졸론
상품명:
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
동의어(영문):
PMP;NSC-12;Radicu;MCI-186;Radicut;NSC-2629;EDARAVONE;NSC-26139;Adaravone;developerz
CBNumber:
CB1287462
분자식:
C10H10N2O
포뮬러 무게:
174.2
MOL 파일:
89-25-8.mol

3-메틸-1-페닐-2-피라졸린-5-온 속성

녹는점
126-128 °C(lit.)
끓는 점
287 °C265 mm Hg(lit.)
밀도
1,12 g/cm3
굴절률
1.6300 (estimate)
인화점
191°C/17mm
저장 조건
Store at RT
용해도
3.30g/l
물리적 상태
Crystalline Powder
색상
Yellow to beige
수소이온지수(pH)
4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
수용성
3 g/L (20 ºC)
Merck
14,6713
BRN
609575
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
CAS 데이터베이스
89-25-8(CAS DataBase Reference)
NIST
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl- (89-25-8)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 1
RTECS 번호 UQ9625000
TSCA Yes
HS 번호 29331990
유해 물질 데이터 89-25-8(Hazardous Substances Data)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

3-메틸-1-페닐-2-피라졸린-5-온 MSDS


Edaravone

3-메틸-1-페닐-2-피라졸린-5-온 C화학적 특성, 용도, 생산

개요

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

화학적 성질

Off white to light yellow powder

Originator

Mitsubishi Pharma (Japan)

용도

antioxidant, lipoxygenase inhibitor

용도

Edaravone inhibits the disease activity in rheumatoid arthritis.

정의

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

상표명

Radicut

위험도

Toxic by ingestion.

생물학적 활성

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Purification Methods

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

3-메틸-1-페닐-2-피라졸린-5-온 준비 용품 및 원자재

원자재

준비 용품


3-메틸-1-페닐-2-피라졸린-5-온 공급 업체

글로벌( 435)공급 업체
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Capot Chemical Co.,Ltd.
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+86 (0)571-858 647 95 sales@capotchem.com China 19919 60
Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 488 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1750 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Kono Chem Co., Ltd
+86-132 8924 6953
info@konochemical.com CHINA 2144 58

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