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Progabide

Progabide 구조식 이미지
카스 번호:
62666-20-0
상품명:
Progabide
동의어(영문):
Gabren;Gabrene;SL-76.002;progabide;Halogabide;C-abren(e);4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide;BUTANAMIDE, 4-[[(4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)METHYLENE]AMINO]-
CBNumber:
CB1296044
분자식:
C17H16ClFN2O2
포뮬러 무게:
334.77
MOL 파일:
62666-20-0.mol

Progabide 속성

녹는점
133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
밀도
1.2822 (estimate)
산도 계수 (pKa)
pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)

안전

독성 LD50 i.p. in mice: 900 mg/kg (Kaplan)

Progabide C화학적 특성, 용도, 생산

개요

Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.

화학적 성질

Bright Yellow Solid

Originator

Synthelabo (France)

용도

Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.

상표명

Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.

World Health Organization (WHO)

Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.

효소 저해제

This anticonvulsant, antidepressive, and anti-parkinson disease drug (FW = 334.78 g/mol; CAS 62666-20-0), which displaces g-aminobutyrate from its binding sites in membranes and behaves as a GABA agonist, inhibits g- aminobutyrate receptor, microsomal epoxide hydrolase, and pyridoxal kinase.

Progabide 준비 용품 및 원자재

원자재

준비 용품


Progabide 공급 업체

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