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세레신 C화학적 특성, 용도, 생산

화학적 성질

Ceresin is a white-to-yellow waxy mixture of hydrocarbons obtained by purification of ozokerite. It occurs as odorless, tasteless, amorphous (noncrystalline) brittle, waxy cakes or pastilles.

용도

ceresin wax (ceresin) is a thickener and a binder with noncomedogenic properties.

생산 방법

Ceresin is prepared by extraction and purification of the native mineral fossil wax ozokerite, which is derived from coal and shale. Ozokerite is mined from deposits in various localities around the world. It is found as irregular mineral veins or as a black mass in clay strata. Mined ozokerite is heated to melt it, and any earth or rock is removed. If necessary, it is heated to 115–1208℃ to remove any moisture and then treated with sulfuric acid or fuming sulfuric acid. After neutralization, it is decolorized using activated charcoal or silica gel, and filtered. If decolorizing is not sufficient, it is repeatedly treated with sulfuric acid and subjected to adsorption filtration to produce more refined ceresin.
Another method of producing ceresin involves dissolving ozokerite in ligroin, treating it with activated clay, and then removing the high-boiling-point fraction.

Pharmaceutical Applications

Ceresin is used as a stiffening agent in creams and ointments, and as an emulsion stabilizer, opacifier, viscosity control agent, and thickener in pharmaceutical protective, topical, and vaginal creams. It is also used in cosmetics and personal care products.
Ceresin is often used as a substitute for ozokerite wax due to its similar properties, and also as a substitute for beeswax and paraffin wax. It acts as a rheological modifier at low concentrations (2–3%) and has the ability to create very small crystallites, which crosslink and establish a network structure that does not allow flow in practical conditions. Ceresin produces stable mixtures with oils and prevents bleeding or sweating of oil, and it produces a lighter cream that is less greasy.
Ceresin is also used for pharmaceutical coating applications of medicaments, for example, protective coatings, enteric coatings, and sustained-release coatings. It has been used in the formulation of multivesicular emulsion topical delivery systems.

Safety

Ceresin is nontoxic, nonhazardous, and safe for use in personal care and cosmetic ingredients in the present practices of concentration and use. The Cosmetic Ingredient Review Expert Panel has concluded that ceresin does not result in dermal sensitization. When formulations containing these ingredients were tested, they produced no skin irritation and the formulations were not phototoxic.
Ceresin may be slightly hazardous on ingestion and inhalation. No definitive information is available on carcinogenicity, mutagenicity, target organs, or developmental toxicity. The FDA has established a cumulative estimated daily intake of ceresin of 0.00035 mg/kg body weight, and a cumulative dietary concentration in food of not more than 7 ppb.

저장

Ceresin should be stored in well-closed containers in a cool, dry, well-ventilated place, away from extreme heat and strong oxidizing agents.

비 호환성

Ceresin is incompatible with strong oxidizing agents. It is compatible with most animal, vegetable, and mineral waxes, as well as mineral oil and petrolatum.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical ointments; vaginal emulsions and creams). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines (topical creams) licensed in the UK. Accepted for use in cosmetics and personal care products marketed in Europe.

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세레신 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Chemson Industrial (Shanghai) Co., Ltd.	86-21-65208861- 8007	sales1@chemson.com.cn	CHINA	117	58
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1011	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

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