Amifostine
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Amifostine 속성
- 녹는점
- 160-1610C
- 끓는 점
- 441.7±51.0 °C(Predicted)
- 밀도
- 1.367±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 물에 용해됩니다.
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 1.28±0.10(Predicted)
- 색상
- 하얀색
- 수용성
- 물에 100mM까지 용해됨
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. 증류수 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 20537-88-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | TE6491000 | ||
| 유해 물질 데이터 | 20537-88-6(Hazardous Substances Data) | ||
| 독성 | cyt-mus-ipr 300 mg/kg CUSCAM 54,1080,85 |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Amifostine C화학적 특성, 용도, 생산
개요
Amifostine, an organic thiophosphate, was introduced for the reduction of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated, preferentially in non-tumor tissues to the active thiol. This agent binds to chemotherapeutic drugs and free radicals released by radiotherapy. The protective effect of amifostine was observed in a wide range of normal organs including bone marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of chemohadiotherapy, indicating an increased therapeutic index for existing cancer treatment. Amifostine is also being evaluated as a cytoprotective in other types of tumors including lung, breast, head and neck cancers. It was reported to be a potent mucolytic with potential in cystic fibrosis.화학적 성질
White Solid용도
It is a thiophosphate derivative of cysteamine; provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment정의
ChEBI: An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.Safety Profile
Poison by intravenous,intramuscular, and intraperitoneal routes. Moderately toxicby ingestion. An experimental teratogen. Otherexperimental reproductive effects. Mutation data reported. When heated todecomposition it emits very toxic fumes of SOx, POAmifostine 준비 용품 및 원자재
원자재
Sodium thiophosphate
N-hydroxyethyl propylene diamine
N-(2-bromoethyl)propane-1,3-diamine
1,2-디아미노프로판
2-하이드록시에틸아미노 프로필아민
브롬화수소
나트륨 티오인산염
준비 용품
Amifostine 공급 업체
글로벌( 230)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 |
info@longyupharma.com | China | 2531 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| Hebei Bonster Technology Co.,Limited | +8613315996897 |
bsterltd.wendy@gmail.com | China | 796 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 |
admin@zhanyaobio.com | China | 2136 | 58 |
Amifostine 관련 검색:
6-아미노 카프로산 에틸파라벤 아미노에틸 에탄올아민 아크릴산메틸 N,N-다이아이소프로필에틸아민 에틸알코올 에틸 5,5-디페닐-2-이소사졸린-3-카르복실레이트 초산에틸 글리신 에틸메르캅탄
N-(n-Butyl)thiophosphoric triamide
Azamethiphos
Tris(trimethylsilyl)phosphate
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts
Zinc Dialkyl Dithio Phosphate(ZDDP)
Anifostine trihydrate
AMIFOSTINE HYDRATE
AMifostine Disulfide