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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 구조식 이미지

카스 번호:: 6318-41-8

상품명:: 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

동의어(영문):: PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K

CBNumber:: CB13232856

분자식:: C11H7NO4S

포뮬러 무게:: 249.24

MOL 파일:: 6318-41-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 20

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 속성

밀도: 1.595±0.06 g/cm3(Predicted)

저장 조건: +2C to +8C

용해도: DMSO에 용해됩니다(최대 25mg/ml).

물리적 상태: 노란색 고체

산도 계수 (pKa): 7.13±0.20(Predicted)

색상: 노란색

안정성: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

안전

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- C화학적 특성, 용도, 생산

개요

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC₅₀ = 70 nM), compared to PI3Kα (IC₅₀ = 240 nM), PI3Kβ (IC₅₀ = 1.45 μM), and PI3Kδ (IC₅₀ =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED₅₀ = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 준비 용품 및 원자재

원자재

준비 용품

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 공급 업체

글로벌( 20)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3444	55
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9440	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
InvivoChem	13549236410	sales@invivochem.cn	China	6712	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- 관련 검색:

Oxaprozin GSK J1 Amlexanox ROLIPRAM 3-METHYLADENINE WORTMANNIN PI3-Kinase α Inhibitor 2 LY 294002 HYDROCHLORIDE