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Cosyntropin

Cosyntropin 구조식 이미지
카스 번호:
16960-16-0
상품명:
Cosyntropin
동의어(영문):
C06926;acth-z;ba30920;ba36716;actholain;cortrosyn;synacthen;synecthen;α1-24-ACTH;ACTH (1-24)
CBNumber:
CB1325409
분자식:
C136H210N40O31S
포뮬러 무게:
2933.47
MOL 파일:
16960-16-0.mol

Cosyntropin 속성

저장 조건
−20°C
용해도
Sparingly soluble in water.
수용성
Soluble in water
InChIKey
ZOEFCCMDUURGSE-SQKVDDBVSA-N
CAS 데이터베이스
16960-16-0(CAS DataBase Reference)

안전

WGK 독일 3
RTECS 번호 GM7915000
HS 번호 2937220000
유해 물질 데이터 16960-16-0(Hazardous Substances Data)

Cosyntropin MSDS


Cosyntropin

Cosyntropin C화학적 특성, 용도, 생산

화학적 성질

White or yellow, amorphous powder.

용도

Hormone (adrenocorticotropic).

Indications

Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.

정의

ChEBI: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of cort costeroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.

상표명

Cortrosyn (Amphastar).

일반 설명

Cosyntropin (Cortrosyn) is a syntheticpeptide containing the first 24 amino acids of natural corticotropin.Cosyntropin is used as a diagnostic agent to testfor adrenal cortical deficiency. Plasma hydrocortisone concentrationis determined before and 30 minutes after theadministration of 250 g of cosyntropin. Most normal responses result in an approximate doubling of the basalhydrocortisone concentration in 30 to 60 minutes. If the responseis not normal, adrenal insufficiency is indicated.Such adrenal insufficiency could be a result of either adrenalor pituitary malfunction, and further testing is requiredto distinguish between the two. Cosyntropin (250 μg infusedwithin 4–8 hours) or corticotropin (80–120 U/day for3–4 days) is administered. Patients with functional adrenaltissue should respond to this dosage. Patients who respondaccordingly are suspected of hypopituitarism, and the diagnosiscan be confirmed by other tests for pituitary function.Patients who have Addison disease, however, show little orno response.

Veterinary Drugs and Treatments

Cosyntropin is used primarily as an alternative to ACTH to test for adrenocortical insufficiency (Addison’s), or hyperadrenocorticism, particularly in animals who have reacted immunologically to corticotropin in the past or if ACTH gel is unavailable.

Cosyntropin 준비 용품 및 원자재

원자재

준비 용품


Cosyntropin 공급 업체

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Cellmano Biotech Limited
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Alpha Biopharmaceuticals Co., Ltd
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Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30003 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2258 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58

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