펜플루라민
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펜플루라민 속성
- 녹는점
- 170°C
- 끓는 점
- bp12 108-112°
- 밀도
- 1.0950 (estimate)
- 저장 조건
- -20°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 기름
- 산도 계수 (pKa)
- pKa 9.10 (Uncertain)
- 색상
- 무색~담황색
- 안정성
- 흡습성
- CAS 데이터베이스
- 458-24-2
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | F,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 11-23/24/25-39/23/24/25 | ||
| 안전지침서 | 16-36/37-45 | ||
| 유해 물질 데이터 | 458-24-2(Hazardous Substances Data) | ||
| 독성 | LD50 i.p. in mice: 144 mg/kg |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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펜플루라민 C화학적 특성, 용도, 생산
용도
Anorexic.정의
ChEBI: A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reu take pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding ehavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertensio .World Health Organization (WHO)
Fenfluramine, dexfenfluramine and phentermine were approved individually more than 20 years ago in the USA for single-drug, short-term treatment of obesity. The manufacturers of fenfluramine and dexfenfluramine have since voluntarily withdrawn both products from the market worldwide. Phentermine remains available.펜플루라민 준비 용품 및 원자재
원자재
펜플루라민하이드로클로라이드
벤조트리플루오라이드
3-브로모벤조트리플루오르화물
수산화칼륨
Para-포름알데하이드
페닐아세토나이트릴
염산
칼륨보로하이드라이드
디클로로메탄
요오드 메탄
산화프로필렌
수소
Aluminium-nickel
준비 용품
펜플루라민 관련 검색:
펜에틸아민 6-플루오로트립타민 염산염
R(-)-FENFLURAMINE HYDROCHLORIDE LESS ACT IVE ENANTIOME,l-fenfluramin
(+)-FENFLURAMINE HYDROCHLORIDE,(+)-fenfluramine hydrochloride--dea*schedule iv I,(s)-fenfluramin
BENFLUOREX HYDROCHLORIDE
FENFLURAMINE
Flucetorex
FENFLURAMINE HYDROCHLORIDE
S(+)-FENFLURAMINE HYDROCHLORIDE SEROTONI N UPTAKE INHI,(+)-Fenfluramine hydrochloride,(+)-Fenfluramine Hydrochlorid
Fenfluramine hydrochloride
DL-3-(4-Fluorophenyl)alanine
3-FLUORO-D-PHENYLALANINE
3-(TRIFLUOROMETHYL)PHENETHYLAMINE
N-NITROSOFENFLURAMINE
(R)-ALPHA-(3-TRIFLUOROMETHYL-BENZYL)-PROLINE-HCL
R(-)-FENFLURAMINE HYDROCHLORIDE
(S)-ALPHA-(3-TRIFLUOROMETHYL-BENZYL)-PROLINE-HCL
N,N-Diethyl-alpha-methyl-m-trifluoromethylphenethylamine