Cefditoren Pivoxil Dimer

Cefditoren Pivoxil Dimer C화학적 특성, 용도, 생산

용도

(E)-Cefditoren Pivoxil Dimer is derivative of Cefditoren Pivoxil. Cefditoren Pivoxil is an antibacterial. Third generation cephalosporin.

제조 방법

The preparation (scheme 1) starts from Cefditoren pivoxil (24.83g, 0.04mol), formalin (3.48g, mass fraction are 37%~40%) and sulfuric acid (0.12g, 1.2mmol), which is added in acetonitrile (125mL), and keeping the temperature 80℃ for 2.0h, then the reaction solution is cooled down to room temperature. The solution is added the mixture of purified water (100mL) and ethyl acetate (200mL) and keep stirring 10min after liquid separation. After being filtered, purified and recrystallized, the finished dimer was got with yield 87.6%.

Scheme 1 The synthesis of Cefditoren Pivoxil Dimer
Zhangying and his coworkers developed another method to cefditoren pivoxil dimer.

Scheme 2 The synthesis of Cefditoren Pivoxil Dimer
Scheme 2 shows the reaction mechanism. First, the cephem compounds (1) nucleophilic attack of the amino Vilsmeier reagent (1), to generate intermediate (3); another molecule cephem compound (I) followed by nucleophilic attack of the amino group resulting intermediate (3) to generate intermediate (5); and then the intermediate (5) dimethylamine off, to form the intermediate (6), the generates the desired products (7) by the transfer of hydrogen ions.

Cefditoren Pivoxil Dimer 준비 용품 및 원자재

원자재

준비 용품

Cefditoren Pivoxil Dimer 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Guangzhou PI PI Biotech Inc	+86-020-81716320 +86-13602409664	Sales@pipitech.com	China	3635	55
Guangzhou Longying Biotechnology Co., Ltd.	15975567350 15975567350	loninbio@sohu.com	China	474	58
PI & PI BIOTECH INC.	020-81716320 17788709170	Sales@pipitech.com	China	2649	58