Trichloroacetyl isocyanate
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Trichloroacetyl isocyanate 속성
- 녹는점
- 135-140 °C
- 끓는 점
- 80-85 °C/20 mmHg (lit.)
- 밀도
- 1.581 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.480(lit.)
- 인화점
- 150 °F
- 저장 조건
- 2-8°C
- 용해도
- 디클로로메탄, 에테르, 테라히드로푸란 및 양성자성 용매와 섞일 수 있습니다.
- 물리적 상태
- 액체
- 색상
- 무색투명~미황색
- 수용성
- 분해
- 감도
- Moisture Sensitive
- BRN
- 971201
- 안정성
- 흡습성, 수분 민감성
- InChIKey
- GRNOZCCBOFGDCL-UHFFFAOYSA-N
- CAS 데이터베이스
- 3019-71-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 14-23/24-34-42-23/24/25-36/37/38 | ||
| 안전지침서 | 23-26-36/37/39-45-8-7/9 | ||
| 유엔번호(UN No.) | UN 2206 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 10-19 | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | II | ||
| HS 번호 | 29291090 |
Trichloroacetyl isocyanate C화학적 특성, 용도, 생산
화학적 성질
clear colorless to slightly yellow liquid용도
Trichloroacetyl isocyanate was used in catalytic one-pot dehydrative glycosylation of 1-hydroxy carbohydrate. It was also used as a reagent for the conversion of alcohols to carbamates.주요 응용
Trichloroacetyl Isocyanate is used as an in situ derivatizing reagent for characterization of alcohols, glycols, phenols, and amines by nuclear magnetic resonance (NMR).It has been reported in the literature that it can be used for the preparation of cefuroxime axetil.제조 방법
Trichloroacetyl isocyanate can be obtained by reacting 2,2,2-trichloroacetamide with oxalyl chloride.Procedure: A reaction mixture of 2,2,2-trichloroacetamide (100 g, 616 mmol, 1.0 eq) in (COCl)2 (725 g, 5.71 mol, 500 mL, 9.28 eq) was heated to 70°C for 24 hours. The reaction mixture was concentrated under vacuum. To the mixture was added 1,2,4-trichlorobenzene (500 mL) and (COCl)2 (116 g, 914 mmol, 80 mL, 1.48 eq). The reaction mixture was stirred at 100°C for 5 hours. Heat to 125°C for 15 hours. The mixture was then heated to 140°C for 5 hours. The reaction mixture was distilled under water pump (72°C-76°C fractions) to give trichloroacetyl isocyanate (60 g, 319 mmol, 52% yield) as a colorless oil.
일반 설명
Conformational stability and vibrational IR and Raman spectra of trichloroacetyl isocyanate has been investigated. Trichloroacetyl isocyanate is commonly employed as in situ derivatizing reagent for the 13C NMR studies of alcohols, phenols and amines. It undergoes 1,5-cycloaddition reaction with anhydro-2-deoxy-D-erythro- and -L-threo-pent-1-enitols and 1,5-anhydro-2-deoxy-D- and -L-arabino-hex-1-enitols to yield [2+2] and [4+2] cycloadducts.Trichloroacetyl isocyanate 준비 용품 및 원자재
원자재
준비 용품
Trichloroacetyl isocyanate 공급 업체
글로벌( 163)공급 업체
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|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
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| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
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| Antai Fine Chemical Technology Co.,Limited | 18503026267 |
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| Hubei Ipure Biology Co., Ltd | +8613367258412 |
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laboratory@coreychem.com | China | 30255 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
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| Wuhan Boye Science And Technology Development Co., Ltd. | 27-81625225 +8615387090420 |
sumihu@boyechemicals.com | CHINA | 215 | 58 |