클로에스테롤 아세트산
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클로에스테롤 아세트산 속성
- 녹는점
- 112-114 °C (lit.)
- 알파
- -44 º (c=2, CHCl3)
- 끓는 점
- 483.49°C (rough estimate)
- 밀도
- 0.9935 (rough estimate)
- 굴절률
- 1.5045 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 불용성
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- ??? (Optical Rotation)
- [α]24/D 44°, c = 2 in chloroform
- 수용성
- 불용성
- Merck
- 14,2201
- BRN
- 2064235
- 안정성
- 흡습성
- LogP
- 10.542 (est)
- CAS 데이터베이스
- 604-35-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 22-24/25-36-26 | ||
| WGK 독일 | 3 | ||
| TSCA | Yes | ||
| 기존화학 물질 | KE-05946 |
클로에스테롤 아세트산 C화학적 특성, 용도, 생산
화학적 성질
white fine crystalline powder or needles용도
Cholesteryl acetate is used in cosmetics, wrist watches, thermometers, propane tank volume indicators, video displays, pharmaceuticals.정의
ChEBI: Cholesteryl acetate is a cholesterol ester obtained by formal acylation of the hydroxy group of cholesterol by acetic acid. It has a role as a human metabolite. It is a cholesteryl ester and an acetate ester.제조 방법
Cholesteryl acetate can be synthesized by the reaction of cholesterol with acetic anhydride in the presence of a catalyst such as pyridine or sulfuric acid. The reaction proceeds as follows:Cholesterol + Acetic anhydride → Cholesteryl acetate + Acetic acid
The reaction is typically carried out at room temperature or slightly elevated temperatures for several hours. The resulting cholesteryl acetate can be purified by recrystallization from a suitable solvent such as ethanol or acetone.
화학 반응
Monophthalic acid epoxidation of cholesteryl acetate:A solution of 10 g (0.023 mole) of cholesteryl acetate (mp 112-114°) in ether (50 ml) is mixed with a solution containing 8.4 g (0.046 mole) of monophthalic acid (Chap. 17, Sec. II) in 250 ml of ether. The solution is kept at reflux for 6 hours and then the solvent is removed by distillation (steam bath). The residue is dried under vacuum and digested with 250 ml of dry chloroform. The mixture was filtered to give 6.7 g of phthalic acid (87% recovery). The solvent in the filtrate was evaporated under reduced pressure and the residue was crystallised from 30 ml of methanol to give 6.0 g (58% yield) of β-oxocholesterol acetate. Recrystallisation gives the pure product, melting point 111-112°. Concentration of the filtrate gives 1.55 g (15 per cent yield) of α-oxocholesterol acetate with a melting point of 101-103° after crystallisation from ethanol.
Purification Methods
Crystallise the acetate from n-pentanol or Me2CO. Also purify it by chromatography through silica gel and eluting with MeOH. [Beilstein 6 III 2607, 6 IV 4004.]클로에스테롤 아세트산 준비 용품 및 원자재
원자재
준비 용품
클로에스테롤 아세트산 공급 업체
글로벌( 322)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 |
sales@anbuchem.com | China | 3000 | 58 |
| Changsha YuTeng New Materials Co., Ltd. | +86-13487087296 +86-13787794286 |
rainbowz@cs-yuteng.com | China | 52 | 58 |
| Shanghai Baoboluo New Material Technology Co., Ltd | +8613659842429 |
13659842429@163.com | China | 25 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 |
sales@kindchem.cn | China | 1226 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15222 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 |
niki@zlchemi.com | China | 7245 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29855 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 |
ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49733 | 58 |