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ChemicalBook >제품 카탈로그 >3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE 구조식 이미지
카스 번호:
622387-85-3
상품명:
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
동의어(영문):
OXSI 2;Syk Inhibitor;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
CBNumber:
CB1364747
분자식:
C18H15N3O3S
포뮬러 무게:
353.39
MOL 파일:
622387-85-3.mol
MSDS 파일:
SDS

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE 속성

저장 조건
Store at -20°C
용해도
DMSO에 용해됨
물리적 상태
주황색 분말 고체.
감도
Light Sensitive
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
그림문자(GHS): GHS hazard pictograms
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE C화학적 특성, 용도, 생산

개요

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.

용도

OXSI 2 is a Syk selective inhibitor.

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE 준비 용품 및 원자재

원자재

준비 용품

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE 공급 업체

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3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE 관련 검색:

(Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(3-(O-TOLYLOXY)PROPYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-N-CYCLOPENTYL-2-(7-ETHYL-3-((1-METHYL-5-(MORPHOLINOSULFONYL)-2-OXOINDOLIN-3-YLIDENE)METHYL)-1H-INDOL-1-YL)ACETAMIDE (Z)-1-ETHYL-5-(MORPHOLINOSULFONYL)-3-((1-(2-(P-TOLYLOXY)ETHYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-2-(7-ETHYL-3-((1-METHYL-5-(MORPHOLINOSULFONYL)-2-OXOINDOLIN-3-YLIDENE)METHYL)-1H-INDOL-1-YL)ACETAMIDE (Z)-3-((1-(3-(2-CHLOROPHENOXY)PROPYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(2-(P-TOLYLOXY)ETHYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-3-((7-ETHYL-1-(2-OXO-2-(PIPERIDIN-1-YL)ETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((1-(2-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((1-(2-CHLORO-6-FLUOROBENZYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(3-PHENOXYPROPYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-1-METHYL-3-((1-(2-(4-METHYLPIPERIDIN-1-YL)-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((5-BROMO-1-(2-PHENOXYETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((7-ETHYL-1-(2-MORPHOLINO-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((7-ETHYL-1-(2-OXO-2-(PYRROLIDIN-1-YL)ETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-3-((1-(2-MORPHOLINO-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((5-BROMO-1-(2-PHENOXYETHYL)-1H-INDOL-3-YL)METHYLENE)-1-ETHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(2-OXO-2-(PIPERIDIN-1-YL)ETHYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-N-(2-METHOXYETHYL)-2-(3-((1-METHYL-5-(MORPHOLINOSULFONYL)-2-OXOINDOLIN-3-YLIDENE)METHYL)-1H-INDOL-1-YL)ACETAMIDE
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