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피록시캄

피록시캄
피록시캄 구조식 이미지
카스 번호:
36322-90-4
한글명:
피록시캄
동의어(한글):
피록시캄;피록시캄(PIROXICAM)
상품명:
Piroxicam
동의어(영문):
Baxo;Erazon;Pirkam;Riacen;Zunden;chf1251;cp16171;Feldene;Geldene;Larapam
CBNumber:
CB1375282
분자식:
C15H13N3O4S
포뮬러 무게:
331.35
MOL 파일:
36322-90-4.mol

피록시캄 속성

녹는점
198-200°C
밀도
1.3664 (rough estimate)
굴절률
1.6320 (estimate)
저장 조건
2-8°C
용해도
Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrous ethanol. It shows polymorphism (5.9).
물리적 상태
neat
산도 계수 (pKa)
6.3 (2:1 dioxane-water)
수용성
Soluble in water, ethanol, chloroform, ethyl acetate.
최대 파장(λmax)
358nm(H2O)(lit.)
Merck
14,7506
InChIKey
QYSPLQLAKJAUJT-UHFFFAOYSA-N
CAS 데이터베이스
36322-90-4(CAS DataBase Reference)
NIST
Piroxicam(36322-90-4)
EPA
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide (36322-90-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,F,T
위험 카페고리 넘버 22-25
안전지침서 26-36
유엔번호(UN No.) UN 2811
WGK 독일 3
RTECS 번호 DL0705000
위험 등급 6.1(b)
포장분류 III
HS 번호 29349990
독성 LD50 orally in mice: 360 mg/kg (Wiseman)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P321 (…) 처치를 하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

피록시캄 MSDS


Piroxicam

피록시캄 C화학적 특성, 용도, 생산

화학적 성질

Off-White to Pale Yellow Solid

용도

Non-steroidal anti-inflammatory with long half-life. Cyclooxygenase inhibitor. Clinically useful NSAID

Indications

Piroxicam (Feldene) is indicated for the treatment of rheumatoid arthritis and osteoarthritis. Piroxicam is a nonspecific COX inhibitor that has a much higher affinity for COX-1 than COX-2. This may account for the large proportion (over 30%) of patients receiving long-term therapy who have reported side effects.Adverse GI reactions have been the most frequently reported side effect, but edema, dizziness, headache, rash, and changes in hematological parameters have also occurred in 1 to 6% of patients. Piroxicam can cause serious GI bleeding, ulceration, and perforation, particularly in the elderly, if the recommended dosage is exceeded or if aspirin is being taken concurrently.

정의

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine.

상표명

Feldene (Pfizer).

일반 설명

Piroxicam (Feldene) is the most widely used oxicam becauseof its once-daily dosing schedule. It is well absorbedafter oral administration and has a plasma half-life of 50hours, thus requiring a dose of only 20 to 30 mg oncedaily. It undergoes extensive hepatic metabolism, catalyzedby CYP2C9 to give 5-hydroxypiroxicam as its majormetabolite. Several piroxicam prodrugshave been synthesized via derivatization of the enol alcoholgroup (amipiroxicam, droxicam, and pivoxicam) to reducepiroxicam-induced GI irritation.

생물학적 활성

Anti-inflammatory; highly selective inhibitor of COX-1 (ratio of IC 50 values for COX-2/COX-1 ~ 600).

Veterinary Drugs and Treatments

In dogs, piroxicam may be beneficial in reducing the pain and inflammation associated with degenerative joint disease, but there are safer alternatives available. Its primary use is in dogs as adjunctive treatment of bladder transitional cell carcinoma. It may also be of benefit in squamous cell carcinomas, mammary adenocarcinoma, and transmissible venereal tumor (TVT). There is some use of it in cats for its anti-tumor effects, but it must be used with extreme caution in this species.

피록시캄 준비 용품 및 원자재

원자재

준비 용품


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