피록시캄
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피록시캄 속성
- 녹는점
- 198-200°C
- 밀도
- 1.3664 (rough estimate)
- 굴절률
- 1.6320 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 물에 거의 녹지 않으며 염화메틸렌에 녹고 무수 에탄올에 약간 녹습니다. 다형성(5.9)을 보여줍니다.
- 산도 계수 (pKa)
- 6.3 (2:1 dioxane-water)
- 색상
- 흰색에서 밝은 노란색
- 수용성
- 물, 에탄올, 에 용해됨클로로포름, 에틸 아세테이트에 용해됩니다.
- 최대 파장(λmax)
- 358nm(H2O)(lit.)
- Merck
- 14,7506
- BCS Class
- 2
- InChIKey
- QYSPLQLAKJAUJT-UHFFFAOYSA-N
- CAS 데이터베이스
- 36322-90-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,F,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-25 | ||
| 안전지침서 | 26-36 | ||
| 유엔번호(UN No.) | UN 2811 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | DL0705000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29349990 | ||
| 독성 | LD50 orally in mice: 360 mg/kg (Wiseman) | ||
| 기존화학 물질 | KE-20696 |
피록시캄 C화학적 특성, 용도, 생산
개요
Piroxieam is a non-steroidal anti-inflammatory drug, of the oxieam class. A contact and photocontact sensitizer, which induced contact dermatitis in a physieal therapist. Piroxieam generally cross reacts with thiosalicylic acid and also with thiomersal. Cross sensitivity is not observed to tenoxicam.화학적 성질
Off-White to Pale Yellow Solid용도
Piroxicam is used in inflammatory and degenerative diseases of the musculoskeletal system that are accompanied by painful symptoms. It is used for rheumatic heart disease, nonspecific infectious polyarthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases associated with inflammation.정의
ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine.Indications
Piroxicam (Feldene) is indicated for the treatment of rheumatoid arthritis and osteoarthritis. Piroxicam is a nonspecific COX inhibitor that has a much higher affinity for COX-1 than COX-2. This may account for the large proportion (over 30%) of patients receiving long-term therapy who have reported side effects.Adverse GI reactions have been the most frequently reported side effect, but edema, dizziness, headache, rash, and changes in hematological parameters have also occurred in 1 to 6% of patients. Piroxicam can cause serious GI bleeding, ulceration, and perforation, particularly in the elderly, if the recommended dosage is exceeded or if aspirin is being taken concurrently.일반 설명
Piroxicam (Feldene) is the most widely used oxicam becauseof its once-daily dosing schedule. It is well absorbedafter oral administration and has a plasma half-life of 50hours, thus requiring a dose of only 20 to 30 mg oncedaily. It undergoes extensive hepatic metabolism, catalyzedby CYP2C9 to give 5-hydroxypiroxicam as its majormetabolite. Several piroxicam prodrugshave been synthesized via derivatization of the enol alcoholgroup (amipiroxicam, droxicam, and pivoxicam) to reducepiroxicam-induced GI irritation.생물학적 활성
Anti-inflammatory; highly selective inhibitor of COX-1 (ratio of IC 50 values for COX-2/COX-1 ~ 600).피록시캄 준비 용품 및 원자재
원자재
에틸알코올
사카린나트륨
2-아미노피리딘
모노클로로초산에틸
BENZTHIAZIDE
요오드 메탄
수산화나트륨
염산
메틸산 나트륨
Desmethyl Piroxicam (Piroxicam Impurity B)
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid isopropyl ester 1,1-dioxide
N-METHYLSACCHARIN
준비 용품
피록시캄 공급 업체
글로벌( 697)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 |
sales@pipharma.com.cn | China | 148 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7786 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 |
wrjmoon2000@163.com | China | 354 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 |
sarah@tnjone.com | China | 874 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |