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Ramosetron hydrochloride

Ramosetron hydrochloride 구조식 이미지

카스 번호:: 132907-72-3

상품명:: Ramosetron hydrochloride

동의어(영문):: ym060;Nasea OD;(R)-YM-060;RAMOSETRON HCL;YM-060;YM060;YM 060;(r)-monohydrochlorid;Ramosetron Hydrochlorid;Ramosetron hydrocloride;RAMOSETRON HYDROCHLORIDE;Ramosetron hydrochloride (API)

CBNumber:: CB1397525

분자식:: C17H18ClN3O

포뮬러 무게:: 315.8

MOL 파일:: 132907-72-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 253

Ramosetron hydrochloride 속성

녹는점: 244-246°C

알파: D -42.9° (c 1.02 in methanol)

저장 조건: -20°C

용해도: H2O: 용해성20mg/mL, 투명

물리적 상태: 가루

색상: 흰색에서 베이지색

optical activity: [α]/D -40 to -45°, c = 1 in methanol

안정성: 흡습성

InChIKey: XIXYTCLDXQRHJO-RFVHGSKJSA-N

CAS 데이터베이스: 132907-72-3(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	22
WGK 독일	3
독성	dog,LD,intravenous,> 30mg/kg (30mg/kg),SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE,Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 117, 1994.

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

NFPA 704

	0
2		0

Ramosetron hydrochloride C화학적 특성, 용도, 생산

개요

Ramosetron Hydrochloride is the only currently available drug indicated for the treatment of male patients with IBS-D in Japan. Ramosetron Hydrochloride was approved in July 1996 under a brand name of Nasea Injection 0.3 mg and in June 1998 under a brand name of Nasea OD tablets 0.1 mg for the treatment of gastrointestinal symptoms (nausea and vomiting) associated with therapy with antineoplastic drugs (e.g., cisplatin).
Nasea was launched in Japan for chemotherapy-induced emesis. Nasea was prepared by a four step sequence via the Vilsmeier-type coupling of 1-methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl-benzimidazole hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and was 8670 times more potent than netoclopramide.

화학적 성질

White Solid

용도

Ramosetron Hydrochloride is a selective serotonin 5-HT3 receptor antagonist and has structurally different from Ondansetron (O655000), Granisetron (G780000). It controls excessive bowel movement and diarrhea by inhibiting 5-HT3 receptors in the intestinal tract. Ramosetron Hydrochloride was approved as film-coated tablets in July 2008 and as orally disintegrating tablets in August 2013 for the indication of treatment of male patients with diarrhea-predominant irritable bowel syndrome.

Ramosetron hydrochloride 준비 용품 및 원자재

원자재

5-[(1-Methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-bezimidazole

준비 용품

Ramosetron hydrochloride 공급 업체

글로벌( 253)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	794	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD	+8615377521700	wangwendy93@gmail.com	China	868	58

Ramosetron hydrochloride 관련 검색:

1H-벤즈아미다졸 인돌-3-아세트산 3-인돌부틸산 인드메타신 이미다졸 인돌 수소 염산 벤젠 Topotecan hydrochloride RAMOSETRON 1-AdaMantanethylaMine ramosetron 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one Rasagiline Impurity 5 Mesylate 1-Methylindole 1-Methyl-1H-indole-3-carboxylic acid (3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one