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Torasemide

Torasemide 구조식 이미지
카스 번호:
56211-40-6
상품명:
Torasemide
동의어(영문):
Unat;TOREM;LUPLAC;Luprac;AC-4464;JDL-464;DEMADEX;GJ-1090;BM-02015;TORADIUR
CBNumber:
CB1397929
분자식:
C16H20N4O3S
포뮬러 무게:
348.42
MOL 파일:
56211-40-6.mol

Torasemide 속성

녹는점
163-164°C
밀도
1.283±0.06 g/cm3(Predicted)
저장 조건
Keep in dark place,Inert atmosphere,Room temperature
용해도
DMSO: soluble18mg/mL
산도 계수 (pKa)
6.44(at 25℃)
물리적 상태
solid
수용성
Soluble
Merck
14,9552
InChIKey
NGBFQHCMQULJNZ-UHFFFAOYSA-N
CAS 데이터베이스
56211-40-6(CAS DataBase Reference)
EPA
3-Pyridinesulfonamide, N-[[(1-methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]- (56211-40-6)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36-36/37/38
안전지침서 26-37/39
WGK 독일 2
RTECS 번호 UT7938000
HS 번호 2935904000
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Torasemide MSDS


Torasemide

Torasemide C화학적 특성, 용도, 생산

개요

Torasemide is a novel loop diuretic launched in 1993 after a 12-year gap from the last diuretic introduction. It is indicated for the treatment of hypertension and edema associated with chronic congestive heart failure, renal disease and hepatic cirrhosis. Torasemide exerts its major diuretic activity on the thick ascending limb of the Henle's loop to promote rapid and marked excretion of water, Na+, Cl-, and to a lesser extent,K+ and Ca2+. Compared with other loop diuretics such as furosemide, torasemide has a stronger antihypertensive action, a higher bioavailability, a longer duration of action that is independent of the renal function, and has no side effects such as paradoxical antidiuresis. The mechanism of its vasodilating effect has been suggested to result from, at least in part, the competitive antagonism of the thromboxane A2 receptor.

개요

Torasemide (Item No. 21312) is an analytical reference standard categorized as a diuretic. Diuretics, including torasemide, have been abused as performance-enhancing drugs and masking agents in doping in sports. This product is intended for research and forensic applications.

화학적 성질

Crystalline Solid

Originator

Hafslund Nycomed Germany; Italy (Norway)

용도

alcohol dehydrogenase inhibitor, antidote

용도

Used as a diuretic

용도

Used as a diuretic.

정의

ChEBI: An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea.

Manufacturing Process

In a 100 ml three-necked flask equipped with magnetic stirrer, condenser, thermometer and dropping funnel 3-sulfonylchloride-4-chloropyridine (10 g, 1 eq., 46.7 mmoles) was suspended in t-butyl-methyl ether (MTBE) (30 ml) at room temperature. Ammonium hydroxide, 25% solution (13.5 ml, 2.13 eq.) was dropped into the suspension in a rate such that the temperature is allowed to increase to 22°-26°C, this temperature was maintained until all the ammonium hydroxide was added. The suspension was then to cooled to room temperature and was stirred for 1 h. The pH of the suspension was adjusted to 80.1 by the addition of a few drops of ammonium hydroxide, 25% solution. The suspension was filtered and washed with water (2 times 10 ml) and the wet product (8 g) dried at 40°C, under the 1 mm Hg vacuum. 3-Sulfonamide- 4-chloropyridine was isolated in 74.4% yield, 6.7 g.
A mixture of 0.01 moles of 3-sulfonamido-4-chloropyridine, 0.02 mole of 3- methylbenzylamine and 50 ml of dry ethanol was heated to reflux temperature for 9 h. After distillation of the ethanol the residue was taken up in an excess of diluted NaOH and the excess of amine was extracted by means of ether.
The aqueous solution was then decolourized with charcoal and filtered, and the filtrate was neutralized with acetic acid. The precipitated product was separated and purified by crystallization from a mixture of water and acetone.The 3-sulfonamido-4-(3-methylbenzyl)amino-pyridine crystallized in the form of beige coloured cristals having a melting point of 184°-186°C. 0.01 mole of 3-sulfonamido-4-(3-methylbenzyl)amino-pyridine was reacted with 0.015 mole of isopropylisocyanate in the presence of 0.02 mole of triethylamine and of 20 ml of dichloromethane, at room temperature for 20 h. After evaporation under vacuum, the residue was taken up in an excess of diluted Na2CO3, filtered off and acidified by means of acetic acid. After precipitation of the product it was filtered and washed several times with ice cold water. The 3-isopropylcarbamoylsulfonamido-4-(3-methylbenzyl)amino_x0002_pyridine (Torsemide) showing as a white powder, has a melting point of 147°- 149°C.

상표명

Torasemide is INN and BAN;Unat;Toradiur.

Therapeutic Function

Diuretic

Biochem/physiol Actions

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Torasemide 준비 용품 및 원자재

원자재

준비 용품


Torasemide 공급 업체

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Capot Chemical Co.,Ltd.
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Henan Tianfu Chemical Co.,Ltd.
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Guangzhou PI PI Biotech Inc
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020-81716319 sales@pipitech.com;87478684@qq.com China 3284 55
Shanghai Yingrui Biopharma Co., Ltd.
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+86-21-34979012 sales03@shyrchem.com CHINA 739 60
career henan chemical co
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Hubei Jusheng Technology Co.,Ltd.
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027-59599243 linda@hubeijusheng.com CHINA 28229 58
Chongqing Chemdad Co., Ltd
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sales@chemdad.com CHINA 37282 58
Shanghai Yingrui Biopharma Co.,Ltd
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Shaanxi Dideu Medichem Co. Ltd
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Zhuozhou Wenxi import and Export Co., Ltd
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Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

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