Nimodipine
|
|
Nimodipine 속성
- 녹는점
- 125°C
- 끓는 점
- 536.21°C (rough estimate)
- 밀도
- 1.3268 (rough estimate)
- 굴절률
- 1.6500 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 메탄올: 62.5mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 2.77±0.70(Predicted)
- 색상
- 하얀색
- Merck
- 14,6551
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- UIAGMCDKSXEBJQ-UHFFFAOYSA-N
- CAS 데이터베이스
- 66085-59-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21/22-48/22 | ||
안전지침서 | 36 | ||
WGK 독일 | 1 | ||
RTECS 번호 | US7975500 | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29333990 | ||
독성 | LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter) |
Nimodipine MSDS
Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
Nimodipine C화학적 특성, 용도, 생산
개요
Nimodipine is a cerebral vasodilating calcium antagonist related to nifedipine. It is indicated for the prophylaxis and treatment of neurological deficits due to cerebral vasospasm after subarachnoid hemorrhage.화학적 성질
Crystalline Solid용도
Nimodipine has been used:- as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
- as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
- in the pharmacological studies for the measurement of spine voltage escape
정의
ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.일반 설명
Nimodipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)- 3,5-pyridinedicarboxylic acid 2-methoxyethyl1-methylethyl ester (Nimotop), is another dihydropyridinecalcium channel blocker but differs in that it dilatesthe cerebral blood vessels more effectively than do the otherdihydropyridine derivatives. This drug is indicated for treatmentof subarachnoid hemorrhage-associated neurologicaldeficits.생물학적 활성
L-type Ca 2+ channel blocker.Nimodipine 준비 용품 및 원자재
원자재
Isopropyl acetoacetate
(2-METHYL-1H-INDOL-3-YL)-옥소-아세트산에틸에스테르
에틸알코올
2-메톡시 에탄올
3-니트로벤즈알데히드
크로톤산
2-Methoxyethyl acetoacetate
암모니아수
준비 용품
Nimodipine 공급 업체
글로벌( 411)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9357 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
Nimodipine 관련 검색:
NIFE디솔 이피엔
Nitrendipine
Nisoldipine
Nimodipine Impurity 5
NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid bis(1-methylethyl) ester
Amlodipine
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester
Nimodipine
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
3-Phenylglutaric acid
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Ethyl 3-(ethylamino)crotonate
Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
dimethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
M-NIFEDIPINE
3-(3-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER