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4-하이드록시벤조 산(

4-하이드록시벤조 산(
4-하이드록시벤조 산( 구조식 이미지
카스 번호:
99-96-7
한글명:
4-하이드록시벤조 산(
동의어(한글):
4-하이드록시벤조산;p-하이드록시안식향산;4-하이드록시벤조산;4-하이드록시벤조익애씨드
상품명:
4-Hydroxybenzoic acid
동의어(영문):
PHBA;LR-68;NSC 4961;FEMA 3986;4-hydroxy;Paraben-acid;4-Carboxyphenol;p-salicylicacid;p-Carboxyphenol;p-hydroxybenzoic
CBNumber:
CB1412080
분자식:
C7H6O3
포뮬러 무게:
138.12
MOL 파일:
99-96-7.mol

4-하이드록시벤조 산( 속성

녹는점
213-217 °C (lit.)
끓는 점
213.5°C (rough estimate)
밀도
1,46 g/cm3
굴절률
1.4600 (estimate)
FEMA
3986 | 4-HYDROXYBENZOIC ACID
인화점
199 °C
저장 조건
Store below +30°C.
용해도
methanol: soluble5%, clear to slightly hazy, colorless to faintly yellow
산도 계수 (pKa)
4.48(at 19℃)
물리적 상태
Crystalline Powder
색상
White to ivory
수소이온지수(pH)
3.3 (1g/l, H2O, 20℃)
수용성
5 g/L (20 ºC)
Merck
14,4812
JECFA Number
957
BRN
970950
InChIKey
FJKROLUGYXJWQN-UHFFFAOYSA-N
CAS 데이터베이스
99-96-7(CAS DataBase Reference)
NIST
Benzoic acid, 4-hydroxy-(99-96-7)
EPA
p-Hydroxybenzoic acid (99-96-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36-36/37/38
안전지침서 26-37/39-36
WGK 독일 1
RTECS 번호 DH1925000
자연 발화 온도 >250 °C
TSCA Yes
HS 번호 29182930
유해 물질 데이터 99-96-7(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 5000 mg/kg
기존화학 물질 KE-20369
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H402 수생생물에 유해함 수생 환경유해성 물질 - 급성 구분 3
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

4-하이드록시벤조 산( MSDS


4-Hydroxybenzenecarboxylic acid

4-하이드록시벤조 산( C화학적 특성, 용도, 생산

개요

4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions. It is isomeric with 2-hydroxybenzoic acid, known as salicylic acid, a precursor to aspirin, and with 3-hydroxybenzoic acid.
4-Hydroxybenzoic acid belongs to the class of aromatic acids, which may be used as a preservative in cosmetics, pharmaceuticals and as a synthetic flavoring agent in food products.

개요

4-Hydroxybenzoic acid is a phenolic acid that has been found in a variety of fruit peels and leaves.

화학적 성질

4-Hydroxybenzoic acid is an odorless white crystalline astringent powder. In pure form, it imparts a sweetish taste at first, which quickly becomes acrid and disagreeable

출처

Reportedly present in apple juice, black currant, cheese, beer, grape brandy, rum, sherry, wines, cocoa, peanut, soybean and wort.

출처

4-Hydroxybenzoic acid is a phenolic acid that has been found in a variety of fruit peels and leaves. It can be found naturally in coconut. It is one of the main catechins metabolites found in humans after consumption of green tea infusions. It is also found in wine, in vanilla, in Macrotyloma uniflorum (horse gram), carob and in Phyllanthus acidus (Otaheite gooseberry).

용도

4-Hydroxybenzoic acid is used as an intermediate for dyes, antiseptics and active pharmaceutical ingredients. It is also used as a food preservative, corrosion inhibitor, anti-oxidant and an emulsifier. It reacts with 6-hydroxynaphthalene-2-carboxylic acid to prepare aromatic polyester called Vectran fiber. It acts as a precursor to prepare p-hydroxyphenylbenzoate, p-acetoxybenzoyl chloride and 4,4'-dihydroxybenzophenone. Further, it is used in paint additives, coating additives, processing aids, electrical and electronic products. In addition to this, it acts as a preservative in cosmetics and some ophthalmic solutions.

용도

p-Hydroxybenzoic acid is of significant commercial importance. The most familiar application is the use of several of its esters as preservatives, known as parabens. Also of interest is the use in liquid crystal polymer applications.

용도

Acetylsalicylic Acid Impurity A

용도

In organic. syntheses; intermediate for dyes, fungicides.

정의

ChEBI: A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.

주요 응용

4-Hydroxybenzoic acid can be used as a starting material to synthesize organic intermediates such as 4-acetoxybenzoic acid and 4-hydroxy-3,5-diiodobenzoic acid.
4-Hydroxybenzoic acid is used as an intermediate for dyes, antiseptics and active pharmaceutical ingredients. It is also used as a food preservative, corrosion inhibitor, anti-oxidant and an emulsifier. It reacts with 6-hydroxynaphthalene-2-carboxylic acid to prepare aromatic polyester called Vectran fiber. It acts as a precursor to prepare p-hydroxyphenylbenzoate, p-acetoxybenzoyl chloride and 4,4′-dihydroxybenzophenone. Further, it is used in paint additives, coating additives, processing aids, electrical and electronic products. In addition to this, it acts as a preservative in cosmetics and some ophthalmic solutions.

제조 방법

Prepared from p-bromophenol or p-hydroxybenzaldehyde, or from saponification of methyl salicylate, a major component of oil of wintergreen.

Aroma threshold values

Detection at 5 ppm (water)

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 174, 1984 DOI: 10.1021/ja00313a035
The Journal of Organic Chemistry, 29, p. 3459, 1964 DOI: 10.1021/jo01035a003

일반 설명

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 4-Hydroxybenzoic acid belongs to the class of aromatic acids, which may be used as a preservative in cosmetics, pharmaceuticals and as a synthetic flavoring agent in food products.

Purification Methods

Crystallise the hydroxyacid from water. [Beilstein 10 IV 345.]

4-하이드록시벤조 산( 준비 용품 및 원자재

원자재

준비 용품


4-하이드록시벤조 산( 공급 업체

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career henan chemical co
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4-하이드록시벤조 산( 관련 검색:

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