ALPHA-MSH

ALPHA-MSH 구조식 이미지
카스 번호:
581-05-5
상품명:
ALPHA-MSH
동의어(영문):
a-MSH;C02758;ALFA-MSH;ALPHA-MSH;-MSH;α-MSH, amide;α-Melanotropin;alpha-Intermedin;ALPHA-MSH, AMIDE;ALPHA-MSN, HUMAN
CBNumber:
CB1440232
분자식:
C77H109N21O19S
포뮬러 무게:
1664.88
MOL 파일:
581-05-5.mol

ALPHA-MSH 속성

밀도
1.48±0.1 g/cm3(Predicted)
저장 조건
2-8°C
용해도
insoluble in EtOH; ≥10.44 mg/mL in H2O with ultrasonic; ≥166.5 mg/mL in DMSO with gentle warming
산도 계수 (pKa)
4.43±0.10(Predicted)
물리적 상태
동결건조된
수용성
물에 용해됩니다(~1 mg/ml).
BRN
741840

안전

안전지침서 22-24/25
WGK 독일 3

ALPHA-MSH C화학적 특성, 용도, 생산

용도

alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

일반 설명

α-Melanocyte-stimulating hormone (α-MSH) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. Pro-inflammatory cytokines or UV light induced epidermal cells such as keratinocytes and melanocytes synthesize and discharge α–MSH. Poopiomelanocortin (POMC) acts as a precursor for α-Melanocyte-stimulating hormone (α-MSH) production.

Purification Methods

Its solubility in H2O is 1mg/mL. It is separated from the extract by ion-exchange on carboxymethyl cellulose, desalted, evaporated and lyophilised, then chromatographed on Sephadex G-25. [Lande et al. Biochemical Preparations 13 45 1971.]

ALPHA-MSH 준비 용품 및 원자재

원자재

준비 용품


ALPHA-MSH 공급 업체

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