헥세티딘
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헥세티딘 속성
- 녹는점
- 25°C
- 끓는 점
- 160 °C/0.4 mmHg (lit.)
- 밀도
- 0.889 g/mL at 25 °C (lit.)
- 굴절률
- 1.4649
- 인화점
- 70°C
- 저장 조건
- 2-8°C
- 용해도
- 아세톤: 용해성(lit.)
- 산도 계수 (pKa)
- 8.3(at 25℃)
- 색상
- 투명 무색
- 수용성
- 물에 섞이거나 혼합하기 어렵지 않습니다.
- Merck
- 14,4703
- BRN
- 161071
- InChIKey
- DTOUUUZOYKYHEP-UHFFFAOYSA-N
- LogP
- 7.150 (est)
- CAS 데이터베이스
- 141-94-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/38-36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 2933599590 | ||
유해 물질 데이터 | 141-94-6(Hazardous Substances Data) |
헥세티딘 C화학적 특성, 용도, 생산
화학적 성질
Hexetidine is a colorless or faint yellow-colored oily liquid with a characteristic amine odor.용도
Hexetidine, mixture of stereoisomers is an antibacterial and antifungal agent. Used in plant-derived composite antimicrobial agent and application thereof in cosmetic.생산 방법
Hexetidine is prepared by hydrogenation under pressure of 1,3- bis(2-ethylhexyl)-5-methyl-4-nitrohexahydropyriminine at 100°C using Raney nickel as a catalyst.일반 설명
The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.위험도
Combustible.Pharmaceutical Applications
Hexetidine is used as an antimicrobial preservative in cosmetics and nonparenteral pharmaceutical formulations. Therapeutically, hexetidine is mainly used as a 0.1% w/v solution in mouthwash formulations for the prevention and treatment of minor local infections, gingivitis, and mouth ulcers.Safety
Hexetidine is mainly used in mouthwashes as a bactericidal and fungicidal antiseptic. It is also used as an antimicrobial preservative and is generally regarded as a relatively nontoxic and nonirritant material at concentrations up to 0.1% w/v. Allergic contact dermatitis and altered olfactory and taste perception have occasionally been reported. Hexetidine is toxic when administered intravenously.Solutions of hexetidine in oil at concentrations of 5–10% w/v cause strong primary irritations without sensitization in humans. Long-term toxicological studies of up to 0.1% w/w of hexetidine in food for 1 year do not show any toxic effect. Fetotoxicity, embryotoxicity, and teratogenicity studies in rats of doses up to 50 mg/kg/day exhibit no sign of toxicity.
LD100 (cat, IV): 5–20 mg/kg
LD50 (dog, oral): 1.60 g/kg
LD50 (mouse, IP): 0.142 g/kg
LD50 (mouse, oral): 1.52 g/kg
LD50 (rat, oral): 0.61–1.43 g/kg
저장
Hexetidine is stable and should be stored in a well-closed container in a cool, dry place. Brass and copper equipment should not be used for the handling or storage of hexetidine.비 호환성
Hexetidine is incompatible with strong oxidizing agents. Salts are formed with mineral and organic acids; strong acids cause opening of the hexahydropyrimidine ring, releasing formaldehyde.Regulatory Status
Included in nonparenteral formulations licensed in Europe.헥세티딘 준비 용품 및 원자재
원자재
준비 용품
헥세티딘 공급 업체
글로벌( 146)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 18192627656 |
1012@dideu.com | China | 3422 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |
헥세티딘 관련 검색:
2-아미노페놀 피리미포스-메틸 아미노트라이메틸렌 포스폰산 글리신 6-아미노 카프로산 다이메틸-p-페닐엔디아민 트리스(하이드록시메틸)아미노메탄 디이소부틸아민 2-에틸핵실아민 메틸에틸케톤
4-Ethyl-5-fluoro-6-hydroxypyrimidine
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