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Losartan potassium

Losartan potassium 구조식 이미지
카스 번호:
124750-99-8
상품명:
Losartan potassium
동의어(영문):
MK-95;MK 954;COZAAR;DUP 753;mk-0954;Aradois;l-158086;dupont753;thanolpotassium;LOSARTAN POTASSIUM
CBNumber:
CB1442564
분자식:
C22H23ClKN6O
포뮬러 무게:
462.01
MOL 파일:
124750-99-8.mol

Losartan potassium 속성

녹는점
263-265°C
저장 조건
Desiccate at RT
용해도
Freely soluble in water and in methanol, slightly soluble in acetonitrile.
물리적 상태
powder or crystals
Merck
14,5583
BRN
5845770
InChIKey
OXCMYAYHXIHQOA-UHFFFAOYSA-N
CAS 데이터베이스
124750-99-8(CAS DataBase Reference)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36/37/39
WGK 독일 3
RTECS 번호 NI6755100
HS 번호 2933290000
유해 물질 데이터 124750-99-8(Hazardous Substances Data)

Losartan potassium C화학적 특성, 용도, 생산

개요

Losartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT1 receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Other reports indicate that losartan may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative response of the vascular wall after coronary angioplasty and surgery.

화학적 성질

White to Off-White Crystalline Powder

Originator

DuPont Merck (U.S.A.)

용도

A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

용도

antihypertensive, AT1 angiotensin II antagonist

용도

Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).

상표명

Cozaar (Merck).

생물학적 활성

Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.

Losartan potassium 준비 용품 및 원자재

원자재

준비 용품


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