에스쿨레틴
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에스쿨레틴 속성
- 녹는점
- 271-273 °C(lit.)
- 끓는 점
- 270.35°C (rough estimate)
- 밀도
- 1.3431 (rough estimate)
- 굴절률
- 1.4500 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 끓는 물, 에테르에 거의 녹지 않습니다. 뜨거운 에탄올, 빙초산에 용해됨
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 1.71(at 25℃)
- 색상
- 연노랑
- pH 범위
- Weak blue uorescence (1.5) to strong blue uorescence (2.0)
- 수용성
- 약간 용해됨
- Merck
- 14,3697
- BRN
- 152788
- 주요 응용
- antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness
- InChIKey
- ILEDWLMCKZNDJK-UHFFFAOYSA-N
- LogP
- 0.980 (est)
- CAS 데이터베이스
- 305-01-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36-37/39 | ||
WGK 독일 | 3 | ||
RTECS 번호 | GN6382500 | ||
HS 번호 | 29322090 |
에스쿨레틴 C화학적 특성, 용도, 생산
화학적 성질
YELLOWISH CRYSTALLINE POWDER용도
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.정의
ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.일반 설명
Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.Purification Methods
It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]에스쿨레틴 준비 용품 및 원자재
원자재
퀴논
[1,3]디옥솔로[4,5-G]크롬-6-원
6,7-DIHYDROXYCOUMARIN-7-벤질에테르
스코폴레틴
3,4-디하이드록시-6-니트로벤잘데하이드
에스쿨린
2,4,5-트리하이드록시벤즈알데하이드
6-히드록시쿠마린
6-HYDROXY-7-METHOXYCOUMARIN
1,2,4-트리아세톡시벤젠
7,8-DIHYDROXY-6-METHOXYCOUMARIN
준비 용품
에스쿨레틴 공급 업체
글로벌( 448)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-18791163155 +86-13119157289 |
13119157289@163.com | China | 2972 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20293 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9328 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |