Enalapril maleate
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Enalapril maleate 속성
- 녹는점
- 143-144,5°C
- 끓는 점
- 0°C
- 알파
- D25 -42.2° (c = 1 in methanol)
- 인화점
- 0°C
- 저장 조건
- 2-8°C
- 용해도
- 메탄올: ≥50 mg/mL, 투명, 무색 내지 노란색
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- pKa1 3.0; pKa2 (25°) 5.4
- 색상
- 흰색에서 황백색까지
- 수용성
- 물, 메탄올, 에탄올에 용해됩니다.
- 최대 파장(λmax)
- 208nm(MeOH)(lit.)
- Merck
- 14,3567
- BCS Class
- 1 (LogP), 3 (CLogP)
- InChIKey
- OYFJQPXVCSSHAI-QFPUQLAESA-N
- CAS 데이터베이스
- 76095-16-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
위험품 표기 | Xi,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-62-63 | ||
안전지침서 | 22-24/25-36/37-26 | ||
유엔번호(UN No.) | 3077 | ||
WGK 독일 | 2 | ||
RTECS 번호 | TW3666000 | ||
HS 번호 | 29339900 | ||
독성 | LD50 oral in rat: 2973mg/kg |
Enalapril maleate C화학적 특성, 용도, 생산
개요
Enalapril maleate is the second angiotensin converting enzyme inhibitor to reach the marketplace. Like captopril, the first entry in this area, enalapril is useful in the treatment of hypertension and congestive heart failure. It has a longer effective half-life than captopril, allowing once or twice-daily dosing, and appears to have a somewhat lower incidence of side effects.화학적 성질
White to Off-White Crystalline Powder용도
Enalapril maleate salt is used as a long-acting ACE inhibitor and antihypertensive, used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma (I50=1.2nM). ACE inhibitors disturb the enin-angiotensin- aldosterone system. Additional ACE inhibitors include: Enalapril, Enalaprilat dihydrate, Enalaprilat, and Enalapril-d5 Maleate Salt, among others.정의
ChEBI: The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angioten in-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal diseas in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.일반 설명
Enalapril maleate, 1-[N[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-L-proline 1 -ethyl estermaleate (Vasotec), is a long-acting ACE inhibitor. It requiresactivation by hydrolysis of its ethyl ester to form thediacid enalaprilat. Enalapril is devoid of the side effects ofrash and loss of taste seen with captopril. These side effectsare similar to those of the mercapto-containing drugpenicillamine. The absence of the thiol group in enalaprilmaleate may free it from these side effects. The half-life is11 hours.Enalapril maleate 준비 용품 및 원자재
원자재
준비 용품
Enalapril maleate 공급 업체
글로벌( 613)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
APOLLO HEALTHCARE RESOURCES | +6596580999 |
sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hebei Dangtong Import and export Co LTD | +8615632927689 |
admin@hbdangtong.com | China | 991 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7786 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 |
sarah@tnjone.com | China | 874 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
Enalapril maleate 관련 검색:
디나트륨 푸마르산염 말레인산
D-Proline
cis-4-Hydroxy-L-proline
L-PROLINE-(4-3H(N))
Enalapril diketopiperazine
Enalapril EP IMpurity A (SSR)
ALMOTRIPTAN
Empagliflozin
Etretinate
Epalrestat
Emedastine EP Impurity F
Enalapril-d5 Maleate Salt
L-Alanyl-L-proline
ENALAPRILAT-D5, SODIUM SALT
Imidazole
Enalapril Maleate USP24
(S,S)-N-(1-ETHOXYCARBONYL-3-PHENYLPROPYL)ALANINE (ECPPA)/ENALAPRIL MALEATE