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Enalapril maleate

Enalapril maleate 구조식 이미지
카스 번호:
76095-16-4
상품명:
Enalapril maleate
동의어(영문):
BQL;Pres;Ednyt;Envas;Nuril;Xanef;MK-421;Enaloc;Enaril;Hytrol
CBNumber:
CB1467853
분자식:
C24H32N2O9
포뮬러 무게:
492.52
MOL 파일:
76095-16-4.mol

Enalapril maleate 속성

녹는점
143-144,5°C
끓는 점
0°C
알파
D25 -42.2° (c = 1 in methanol)
인화점
0°C
저장 조건
-20°C Freezer
용해도
methanol: ≥50 mg/mL, clear, colorless to yellow
물리적 상태
powder
산도 계수 (pKa)
pKa1 3.0; pKa2 (25°) 5.4
색상
white to off-white
수용성
Soluble in water, methanol, and ethanol.
최대 파장(λmax)
208nm(MeOH)(lit.)
Merck
14,3567
CAS 데이터베이스
76095-16-4(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,Xn
위험 카페고리 넘버 36/37/38-62-63
안전지침서 22-24/25-36/37-26
유엔번호(UN No.) 3077
WGK 독일 2
RTECS 번호 TW3666000
HS 번호 29339900
유해 물질 데이터 76095-16-4(Hazardous Substances Data)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281 요구되는 개인 보호구를 착용하시오

Enalapril maleate C화학적 특성, 용도, 생산

개요

Enalapril maleate is the second angiotensin converting enzyme inhibitor to reach the marketplace. Like captopril, the first entry in this area, enalapril is useful in the treatment of hypertension and congestive heart failure. It has a longer effective half-life than captopril, allowing once or twice-daily dosing, and appears to have a somewhat lower incidence of side effects.

화학적 성질

White to Off-White Crystalline Powder

Originator

Merck (USA)

용도

sunscreen

용도

An antihypertensive. An angiotensin-converting enzyme (ACE) inhibitor.

정의

ChEBI: The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angioten in-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal diseas in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.

상표명

RENITEN

일반 설명

Enalapril maleate, 1-[N[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-L-proline 1 -ethyl estermaleate (Vasotec), is a long-acting ACE inhibitor. It requiresactivation by hydrolysis of its ethyl ester to form thediacid enalaprilat. Enalapril is devoid of the side effects ofrash and loss of taste seen with captopril. These side effectsare similar to those of the mercapto-containing drugpenicillamine. The absence of the thiol group in enalaprilmaleate may free it from these side effects. The half-life is11 hours.

Veterinary Drugs and Treatments

The principle use of enalapril/enalaprilat in veterinary medicine at present is as a vasodilator in the treatment of heart failure. Recent studies have demonstrated that enalapril, particularly when used in conjunction with furosemide, does improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. It may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and protein losing nephropathies.
While ACE inhibitors are a mainstay for treating hypertension in humans, they have not been particularly useful in treating hypertension in dogs or cats.

Enalapril maleate 준비 용품 및 원자재

원자재

준비 용품


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