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글리직 산 암모늄 염

글리직 산 암모늄 염
글리직 산 암모늄 염 구조식 이미지
카스 번호:
53956-04-0
한글명:
글리직 산 암모늄 염
동의어(한글):
글리직산암모늄염;글리직산암모늄염;암모늄글리시리제이트
상품명:
Glycyrrhizic acid ammonium salt
동의어(영문):
GLYCAMIL;ammoniate;glycyrram;Glycyrrhiz;Magnasweet;GLYCYRRHIZICAMMONIUM;AMMONIUMGLYCYRRHIZIN;ammoniumglycyrrhizate;GLYCYRRHIZIC ACID, NH4;Ammoniumglycynhizinato
CBNumber:
CB1492372
분자식:
C42H65NO16
포뮬러 무게:
839.96
MOL 파일:
53956-04-0.mol

글리직 산 암모늄 염 속성

녹는점
>200°C (dec.)
끓는 점
768.56°C (rough estimate)
밀도
1.1846 (rough estimate)
굴절률
49 ° (C=1.5, EtOH)
FEMA
2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
저장 조건
2-8°C
용해도
Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.
물리적 상태
Powder or Crystals
색상
Yellow to yellow-green
optical activity
[α]20/D +48±4°, c = 1% in ethanol: water (1:1)
BRN
3897076
InChIKey
ILRKKHJEINIICQ-YDYGGSECSA-N
CAS 데이터베이스
53956-04-0
EPA
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy- 11-oxo-30-norolean-12-en- 3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt(53956-04-0)

안전

유엔번호(UN No.) UN 3077 9 / PGIII
WGK 독일 2
RTECS 번호 LZ6500000
F 고인화성물질 3-10
HS 번호 29389090

글리직 산 암모늄 염 C화학적 특성, 용도, 생산

개요

§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

화학적 성질

Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

화학적 성질

white to slightly yellow powder

용도

Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.

용도

anti-cancer agent

용도

pharmaceutical excipient, GRAS, sweetener

용도

Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.

Anticancer Research

Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.

Purification Methods

Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]

글리직 산 암모늄 염 준비 용품 및 원자재

원자재

준비 용품


글리직 산 암모늄 염 공급 업체

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