글리직 산 암모늄 염

글리직 산 암모늄 염 MSDS

3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid ammonium salt

글리직 산 암모늄 염 C화학적 특성, 용도, 생산

개요

§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

화학적 성질

Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

화학적 성질

white to slightly yellow powder

용도

Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.

용도

anti-cancer agent

용도

pharmaceutical excipient, GRAS, sweetener

용도

Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.

Anticancer Research

Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.

Purification Methods

Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]

글리직 산 암모늄 염 준비 용품 및 원자재

원자재

준비 용품

글리직 산 암모늄 염 공급 업체

공급자	전화	팩스	이메일	국가	제품 수	이점
Chengdu Biopurify Phytochemicals Ltd.	18080483897		maggie@biopurify.com	CHINA	2258	58
Shenzhen Sendi Biotechnology Co.Ltd.	0755-23311925 18102838259	0755-23311925	Abel@chembj.com	CHINA	3194	55
Henan DaKen Chemical CO.,LTD.	+86-371-55531817		info@dakenchem.com	CHINA	21676	58
Henan Tianfu Chemical Co.,Ltd.	0371-55170693	0371-55170693	info@tianfuchem.com	CHINA	20672	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555	+86-021-57951555	jack.li@time-chemicals.com	CHINA	1365	55
Hefei TNJ Chemical Industry Co.,Ltd.	86-0551-65418684 18949823763	86-0551-65418684	info@tnjchem.com	China	1861	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038		zheyansh@163.com	CHINA	3623	58
career henan chemical co	+86-371-86658258		sales@coreychem.com	CHINA	30001	58
Chemwill Asia Co.,Ltd.	86-21-51086038	86-21-51861608	chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com	CHINA	23980	58
Hubei Jusheng Technology Co.,Ltd.	86-18871470254	027-59599243	sales@jushengtech.com	CHINA	28236	58

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