설파퓨라졸
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설파퓨라졸 속성
- 녹는점
- 195°C
- 끓는 점
- 482.2±55.0 °C(Predicted)
- 밀도
- 1.3486 (rough estimate)
- 굴절률
- 1.6630 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- 아세톤: 완전50mg/ml
- 산도 계수 (pKa)
- 5.0(at 25℃)
- 색상
- 흰색에서 밝은 갈색까지
- 수용성
- 22.5&C에서 <0.1g/100mL
- 최대 파장(λmax)
- 271nm(MeOH)(lit.)
- Merck
- 14,8952
- BRN
- 6737262
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- CAS 데이터베이스
- 127-69-5(CAS DataBase Reference)
- IARC
- 3 (Vol. 24, Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | WO9100000 | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29350030 | ||
유해 물질 데이터 | 127-69-5(Hazardous Substances Data) | ||
독성 | LD50 orally in mice: 6800 mg/kg (Seki) | ||
기존화학 물질 | KE-01317 |
설파퓨라졸 C화학적 특성, 용도, 생산
화학적 성질
white to cream powder용도
Sulfisoxazole is a sulfonamide based antibacterial that exhibits activity against wide spectrum of gram-negative and gram-positive bacterium.정의
ChEBI: A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.Antimicrobial activity
Like all examined sulfanilamides, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci, and also colon bacillus. However, about 90% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids, which makes it the drug of choice for many systemic infections. Synonyms of this drug are gantrisin, fultrxin, sulfazin, sulfolar, and others.일반 설명
Sulfisoxazole’s plasmahalf-life is 6 hours. This compound is a white, odorless,slightly bitter, crystalline powder. Its pKa is 5.0. At pH 6,this sulfonamide has a water solubility of 350 mg in100 mL, and its acetyl derivative has a solubility of 110 mgin 100 mL of water.Sulfisoxazole possesses the action and the uses of othersulfonamides and is used for infections involving sulfonamide-sensitive bacteria. It is claimed to be effective in thetreatment of Gram-negative urinary infections.공기와 물의 반응
May be sensitive to prolonged exposure to air and light. Sensitive to heat. Slightly soluble in water.화재위험
Flash point data for Sulfisoxazole are not available; however, Sulfisoxazole is probably combustible.Pharmaceutical Applications
3,4-Dimethyl-5-sulfanilamidoisoxazole. It is highly soluble, even in acid urine. The spectrum and potency are typical of the group. It is well absorbed, achieving a concentration of around 20 mg/L 3–4 h after a 2 g oral dose.Side effects are those common to other sulfonamides. It is less prone than some other members of the group to cause renal problems. Its principal use is in urinary tract infection, and is present in some ophthalmic preparations.
생물학적 활성
A selective ET A endothelin receptor antagonist (IC 50 values are 600 and 2200 nM for ET A and ET B receptors respectively).Safety Profile
Mildly toxic by ingestion. An experimental teratogen. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.설파퓨라졸 준비 용품 및 원자재
원자재
염산
N(4)-acetylsulfisoxazole
Carbamic acid, (3,4-dimethyl-5-isoxazolyl)-, 1,1-dimethylethyl ester (9CI)
N-(3,4-dimethyl-5-isoxazolyl)-4-nitrobenzenesulfonamide
4-Aminobenzene-1-sulfonyl chloride
3,4-Dimethylisoxazol-5-amine
준비 용품
설파퓨라졸 공급 업체
글로벌( 263)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12452 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2504 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9354 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 |
1047@dideu.com | China | 3984 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 12333 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |