설파퓨라졸

설파퓨라졸
설파퓨라졸 구조식 이미지
카스 번호:
127-69-5
한글명:
설파퓨라졸
동의어(한글):
설프이속사졸;설파퓨라졸;설피속사졸;설피스옥사졸
상품명:
Sulfisoxazole
동의어(영문):
SULFAFURAZOLE;SIZ;SULFISOXAZOL;sulphisoxazole;Sosol;vagilia;Sulsoxin;Sulfalar;Gantrisin;SULFAFURAZOL
CBNumber:
CB1495500
분자식:
C11H13N3O3S
포뮬러 무게:
267.3
MOL 파일:
127-69-5.mol
MSDS 파일:
SDS

설파퓨라졸 속성

녹는점
195°C
끓는 점
482.2±55.0 °C(Predicted)
밀도
1.3486 (rough estimate)
굴절률
1.6630 (estimate)
저장 조건
Keep in dark place,Inert atmosphere,2-8°C
용해도
아세톤: 완전50mg/ml
산도 계수 (pKa)
5.0(at 25℃)
색상
흰색에서 밝은 갈색까지
수용성
22.5&C에서 <0.1g/100mL
최대 파장(λmax)
271nm(MeOH)(lit.)
Merck
14,8952
BRN
6737262
안정성
안정적인. 강한 산화제와 호환되지 않습니다.
CAS 데이터베이스
127-69-5(CAS DataBase Reference)
NIST
Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-(127-69-5)
IARC
3 (Vol. 24, Sup 7) 1987
EPA
Sulfisoxazole (127-69-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 2
RTECS 번호 WO9100000
위험 등급 IRRITANT
HS 번호 29350030
유해 물질 데이터 127-69-5(Hazardous Substances Data)
독성 LD50 orally in mice: 6800 mg/kg (Seki)
기존화학 물질 KE-01317
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2 0

설파퓨라졸 MSDS


Sulfafurazole

설파퓨라졸 C화학적 특성, 용도, 생산

화학적 성질

white to cream powder

용도

Sulfisoxazole is a sulfonamide based antibacterial that exhibits activity against wide spectrum of gram-negative and gram-positive bacterium.

정의

ChEBI: A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.

Antimicrobial activity

Like all examined sulfanilamides, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci, and also colon bacillus. However, about 90% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids, which makes it the drug of choice for many systemic infections. Synonyms of this drug are gantrisin, fultrxin, sulfazin, sulfolar, and others.

일반 설명

Sulfisoxazole’s plasmahalf-life is 6 hours. This compound is a white, odorless,slightly bitter, crystalline powder. Its pKa is 5.0. At pH 6,this sulfonamide has a water solubility of 350 mg in100 mL, and its acetyl derivative has a solubility of 110 mgin 100 mL of water.Sulfisoxazole possesses the action and the uses of othersulfonamides and is used for infections involving sulfonamide-sensitive bacteria. It is claimed to be effective in thetreatment of Gram-negative urinary infections.

공기와 물의 반응

May be sensitive to prolonged exposure to air and light. Sensitive to heat. Slightly soluble in water.

화재위험

Flash point data for Sulfisoxazole are not available; however, Sulfisoxazole is probably combustible.

Pharmaceutical Applications

3,4-Dimethyl-5-sulfanilamidoisoxazole. It is highly soluble, even in acid urine. The spectrum and potency are typical of the group. It is well absorbed, achieving a concentration of around 20 mg/L 3–4 h after a 2 g oral dose.
Side effects are those common to other sulfonamides. It is less prone than some other members of the group to cause renal problems. Its principal use is in urinary tract infection, and is present in some ophthalmic preparations.

생물학적 활성

A selective ET A endothelin receptor antagonist (IC 50 values are 600 and 2200 nM for ET A and ET B receptors respectively).

Safety Profile

Mildly toxic by ingestion. An experimental teratogen. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

설파퓨라졸 준비 용품 및 원자재

원자재

준비 용품


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