ENNIATIN B

ENNIATIN B 구조식 이미지
카스 번호:
917-13-5
상품명:
ENNIATIN B
동의어(영문):
ENNIATIN B;N-Methylcyclo(L-Val-D-Hmb-N-methyl-L-Val-D-Hmb-N-methyl-L-Val-D-Hmb-);(3S,6R,9S,12R,15S,18R)-3,6,9,12,15,18-Hexaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone;Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl]
CBNumber:
CB1677384
분자식:
C33H57N3O9
포뮬러 무게:
639.83
MOL 파일:
917-13-5.mol

ENNIATIN B 속성

저장 조건
-20°C
용해도
DMSO: 용해성10mg/mL
물리적 상태
백색 내지 황백색의 결정성 고체.
끓는 점
827.0±65.0 °C(Predicted)
밀도
1.036±0.06 g/cm3(Predicted)
녹는점
229 °C
산도 계수 (pKa)
-1.08±0.70(Predicted)
안전
  • 위험 및 안전 성명
위험품 표기 T
위험 카페고리 넘버 23/24/25
안전지침서 45
유엔번호(UN No.) 2811
WGK 독일 3
위험 등급 6.1(a)
포장분류 I
HS 번호 29419000
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
NFPA 704
0
4 0

ENNIATIN B C화학적 특성, 용도, 생산

용도

Enniatins are a family of depsipeptide ionophores, produced several Fusarium species. More recently, the effects of the ennitins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin B is the most studied of four major analogues of the enniatin complex.

정의

ChEBI: An enniatin obtained from formal cyclocondensation of three N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-valine units.

Biochem/physiol Actions

Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42). Enniatins B and B1 inhibit the multi-drug resistance transporter Pdr5p from Saccharomyces cerevisiae, indicating their beneficial potential in cases of drug resistant patients.

ENNIATIN B 준비 용품 및 원자재

원자재

준비 용품


ENNIATIN B 공급 업체

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