눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
Pregnenolone C화학적 특성, 용도, 생산
개요
Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid
hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a
number of physiologically active C21 steroids, including the female sex hormone progesterone and the
adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the
two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19
steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18
female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.
화학적 성질
white to off-white powder
용도
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an
tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
정의
ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
일반 설명
Pregnenolone is an endogenous steroid hormone involved in the biological synthesis of other hormones. Pregnenolone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase deficiency has been ruled out. This Certified Spiking Solution? is suitable for use in LC-MS/MS testing methods as a starting material in the preparation of calibrators, controls and linearity standards.
