이소퀴놀린
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이소퀴놀린 속성
- 녹는점
- 26-28 °C (lit.)
- 끓는 점
- 242-243 °C (lit.)
- 밀도
- 1.099 g/mL at 25 °C (lit.)
- 증기압
- 5Pa at 20℃
- FEMA
- 2978 | ISOQUINOLINE
- 굴절률
- n
20/D 1.623(lit.)
- 인화점
- 225 °F
- 저장 조건
- 2-8°C
- 용해도
- 5g/L
- 물리적 상태
- 저융점 고체
- 산도 계수 (pKa)
- 5.42(at 20℃)
- 색상
- 연한 갈색
- 수소이온지수(pH)
- 7.5 (5g/l, H2O, 20℃)
- 냄새
- 트리아세틴 중 0.10%. 달콤한 발삼 허브 벤즈알데히드 아니스
- ?? ??
- 발사믹
- 수용성
- 실질적으로 불용성
- Merck
- 14,5222
- JECFA Number
- 1303
- BRN
- 107549
- Dielectric constant
- 10.7(20℃)
- InChIKey
- AWJUIBRHMBBTKR-UHFFFAOYSA-N
- LogP
- 2.08
- 해리상수
- 5.19 at 25℃
- CAS 데이터베이스
- 119-65-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 22-24-38-52/53-36/38-21/22-45 | ||
안전지침서 | 36/37-45-36/37/39-61-53 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 2 | ||
RTECS 번호 | NW6825000 | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29334900 | ||
독성 | LD50 orally in rats: 360 mg/kg (Smyth) | ||
기존화학 물질 | KE-21757 |
이소퀴놀린 C화학적 특성, 용도, 생산
개요
Isoquinoline, also known as 2-azanaphthalene, benzo[c]pyridine, or 2-benzanine, is a structural isomer of quinoline. It has structural and spectroscopic properties similar to quinoline. Isoquinoline was first isolated in 1885 by Hoogewerf and van Dorp from the quinoline fraction of coal tar by fractional crystallization. It is used to prepare dyes, insecticides, and antimalarial compounds, among other things.화학적 성질
Isoquinoline is a colorless hygroscopic liquid at temperatures above its melting point with a heavy sweet balsamic, herbaceous odor. Impure samples can appear brownish, as is typical for nitrogen heterocycles. Isoquinoline is a slightly stronger base than quinoline (pKa=5.14) and has a larger dipole of 2.60D.용도
Isoquinolines are used in the manufacture of dyes, paints, insecticides and antifungals. It is also used as a solvent for the extraction of resins and terpenes, and as a corrosion inhibitor.Isoquinoline (isq) has been used:
in the preparation of cis-[(dcbH2)2Ru(isq)2](ClO4)2 [dcbH2 = 4,4′-(CO2H)2-2,2′-bipyridine].
to investigate the toxicity of three two-ring and five three-ring azaarenes to the green alga Scenedesmus acuminatus and its relationship with molecular structure.
제조 방법
Bischler-Napieralski synthesis is used to synthesize isoquinolines. β-phenylethylamine is acylated, and then cyclodehydrated using phosphoryl chloride, phosphorus pentoxide or other Lewis acids to yield dihydroisoquinoline, which can be aromatized by dehydrogenation with palladium, for example in the synthesis of papaverine, a pharmacologically active isoquinoline alkaloid.Pictet-Spengler synthesis is another method of preparing isoquinolines. β-phenylethylamine reacts with an aldehyde to produce an imine, which undergoes acid-catalysed cyclization, resulting in the synthesis of the tetrahydroisoquinoline system. Again, tetrahydroisoquinoline can be aromatized by palladium dehydrogenation to produce an isoquinoline system.
정의
ChEBI: Isoquinoline is an ortho-fused heteroarene that is a benzopyridine in which the N atom not directly attached to the benzene ring. It is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines.생산 방법
High-temperature coal tar contains an average of 0.2% isoquinoline. It is separated by distillation from the lower-boiling quinoline and the higherboiling 2-methylquinoline of the quinoline base mixture. Further refining is based on the fact that isoquinoline, in contrast to quinoline and 2-methylquinoline, cannot be hydrated but can be crystallized at low temperature.Isoquinoline can by synthesized, for example, via the Bischler–Napieralski reaction by cyclodehydration of N-acyl derivatives of b-phenylethylamine with Lewis acids and subsequent dehydrogenation.
일반 설명
Isoquinoline is one of the very few heterocyclic compounds in which numbering of the ring atoms does not start on the hetero atom.It consists of a benzene ring fused to the β- and Y-positions of a pyridine ring.Isoquinoline has an odor reminiscent of benzaldehyde and anise. Isoquinoline may be obtained from coal tar (238 - 250°C boiling fraction); it is isolated as the sulfate or as is by repeated freezing.
건강위험
The toxic properties of this compound aresimilar to those of quinoline. It is moderatelytoxic in rats and rabbits by oral routeand skin absorption. The oral LD50 value inrats is 360 mg/kg. The irritation effects onskin and eyes in rabbits were moderate tosevere. Carcinogenicity due to isoquinolinein animals or humans is not known. The histidinereversion–Ames test for mutagenicitywas inconclusive.Purification Methods
Dry isoquinoline with Linde type 5A molecular sieves or Na2SO4 and fractionally distil at reduced pressure. Alternatively, it can be refluxed with, and distilled from, BaO. It is also purified by fractional crystallisation from the melt and distilled from zinc dust. It forms a phosphate (m 135o) and a picrate (m 223o), which are purified by crystallisation, and the free base can be recovered and distilled. [Packer et al. J Am Chem Soc 80 905 1958.] The procedure for purification via the picrate comprises the addition of quinoline to picric acid dissolved in the minimum volume of 95% EtOH to yield yellow crystals which are washed with EtOH and air dried before recrystallising from acetonitrile. The crystals are dissolved in dimethyl sulfoxide (previously dried over 4A molecular sieves) and passed through a basic alumina column, on which picric acid is adsorbed. The free base in the effluent is extracted with n-pentane and distilled under vacuum. Traces of solvent from small quantities are removed by vapour phase chromatography. The hydrochloride crystallises from EtOH with m 193o. [Mooman & Anton J Phys Chem 80 2243 1976, Beilstein 20 II 236, 20 III/IV 3410, 20/7 V 333.]이소퀴놀린 준비 용품 및 원자재
원자재
준비 용품
8-Aminoisoquinoline
이소퀴놀린 N-옥사이드
퀴놀린
FASUDIL
1-이소퀴놀린카보나이트릴
Isoquinoline-4-carbaldehyde
1-CYANO-2-BENZOYL-1,2-DIHYDROISOQUINOLINE
Dyestuff
4-Bromo-1-chloroisoquinoline
8-Bromoisoquinoline
ISOQUINOLINE-5-SULFONYL CHLORIDE
LYCORINE
4-Isoquinolineboronic acid
퀴날딘
Praziquantel
5-이소퀴놀린술폰산
5-Hydroxyisoquinoline
이소퀴놀린 공급 업체
글로벌( 455)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 |
admin@hbsaisier.cn | China | 747 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
이소퀴놀린 관련 검색:
이소퀴노일린-1-카르복실산 퀴놀린 1-이소퀴놀린카보나이트릴 에티듐 브로마이드 페난트리딘 1-이소카보스타이릴 디미듐 브로마이드 이소퀴놀린
7-Isoquinolinecarbonitrile(9CI)
Isoquinoline-5-boronic acid
Isoquinoline-4-carboxylic acid
POTASSIUM ISOQUINOLINE-4-TRIFLUOROBORATE
Isoquinoline-5-sulphonyl chloride hydrochloride
ISOQUINOLIN-3-AMINE
ISOQUINOLINE-5-CARBOXYLIC ACID
1,2,3,4-TETRAHYDROISOQUINOLINE
5-Bromoisoquinoline
Isoquinoline-3-carboxylic acid