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노르플록사신

노르플록사신
노르플록사신 구조식 이미지
카스 번호:
70458-96-7
한글명:
노르플록사신
동의어(한글):
노르플록사신
상품명:
Norfloxacin
동의어(영문):
Noflo;4803P;MK-366;am-715;D00210;Norflo;Utinor;Zomxin;noroxin;Barazan
CBNumber:
CB1711035
분자식:
C16H18FN3O3
포뮬러 무게:
319.33
MOL 파일:
70458-96-7.mol

노르플록사신 속성

녹는점
220°C
밀도
1.2504 (estimate)
저장 조건
2-8°C
용해도
Very slightly soluble in water, slightly soluble in acetone and in ethanol (96 per cent).
물리적 상태
Crystalline Powder
산도 계수 (pKa)
pKa1 6.34; pKa2 8.75(at 25℃)
색상
White to yellow
수용성
Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water
Merck
14,6700
InChIKey
OGJPXUAPXNRGGI-UHFFFAOYSA-N
CAS 데이터베이스
70458-96-7(CAS DataBase Reference)

안전

위험품 표기 Xn
위험 카페고리 넘버 20/21/22-36/37/38
안전지침서 26-37/39-24/25
WGK 독일 2
RTECS 번호 VB2005000
위험 등급 IRRITANT
HS 번호 29335990
독성 LD50 in mice, rats (mg/kg): >4000 orally (both species); 1500 s.c. (both species); 470, >500 i.m.; 220, 270 i.v. (Irikura)

노르플록사신 MSDS


N-Desmethylpefloxacin

노르플록사신 C화학적 특성, 용도, 생산

개요

Norfloxacin is the first of the third generation nalidixic acid analogs to reach the marketplace. It exhibits potent in vitro and in vivo activity against Pseudomonas, enteric gram-negative rods and gram-positive cocci. Norfloxacin is orally effective in the treatment of urinary tract infections, including those due to organisms refractory to many other agents.

화학적 성질

Off-white to light yellow cryst powder

Originator

Kyorin (Japan)

용도

An antibacterial. Fluorinated quinolone antibacterial

용도

Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.

정의

ChEBI: A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enz me called DNA gyrase.

상표명

Chibroxin (Merck); Noroxin (Merck).

Antimicrobial activity

It is active against a wide range of Gram-negative bacteria, including Enterobacteriaceae and Campylobacter spp. Ps. aeruginosa, Acinetobacter, Serratia and Providencia spp. are weakly susceptible (and often resistant). It has no useful activity against anaerobes, Chlamydia, Mycoplasma and Mycobacterium spp.

Pharmaceutical Applications

A 6-fluoro, 7-piperazinyl quinoline available for oral administration and as an ophthalmic ointment.

Pharmacokinetics

Oral absorption: 50–70%
Cmax 400 mg oral :1.5 mg/L after 1–1.5 h
Plasma half-life :3–4 h
Volume of distribution: 2.5–3.1 L/kg
Plasma protein binding: 15%
absorption and distribution
Norfloxacin displays linear kinetics. There is no significant accumulation with the recommended dosage of 400 mg every 12 h. Food slightly delays but does not otherwise impair absorption. Antacids reduce absorption. It is widely distributed, but concentrations in tissues other than those of the urinary tract are low: levels in the prostate are around 2.5 mg/g.
Metabolism and excretion
Six or more inactive metabolites are produced. Around 30% of a dose appears as unchanged drug in the urine and <10% as metabolites, producing peak concentrations of microbiologically active drug of around 100–400 mg/L. Urinary recovery is halved by probenecid, with little effect on the plasma concentration. The apparent plasma elimination half-life increases with renal impairment, rising to around 8 h in the anuric patient. Some of the drug appears in the bile where concentrations three- to seven-fold greater than the simultaneous plasma levels are achieved, but this is not a significant route of elimination and hepatic impairment is without effect. Very variable quantities, averaging 30% of a dose, appear in the feces, producing concentrations of active agent of around 200–2000 mg/kg.

Clinical Use

Complicated and uncomplicated urinary tract infections (including prophylaxis in recurrent infections), prostatitis
Uncomplicated gonorrhea
Gastroenteritis caused by Salmonella, Shigella and Campylobacter spp., Vibrio cholerae
Conjunctivitis (ophthalmic preparation)

부작용

Untoward reactions are those common to the fluoroquinolones. Gastrointestinal tract disturbances, which are generally mild, have been reported in 2–4% of patients. CNS disturbances have largely been limited to headache, drowsiness and dizziness. Co-administration with theophylline results in increased plasma theophylline levels.

노르플록사신 준비 용품 및 원자재

원자재

준비 용품


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