노르플록사신
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노르플록사신 속성
- 녹는점
- 220°C
- 끓는 점
- 555.8±50.0 °C(Predicted)
- 밀도
- 1.2504 (estimate)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 물에는 매우 약간 용해되고, 아세톤과 에탄올(96%)에는 약간 용해됩니다.
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- pKa1 6.34; pKa2 8.75(at 25℃)
- 색상
- 흰색에서 노란색으로
- 수용성
- 아세트산에 용해됩니다. 아세톤이나 클로로포름에도 용해됩니다. 물에 약간 용해됨
- Merck
- 14,6700
- 안정성
- 흡습성
- InChI
- InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
- InChIKey
- OGJPXUAPXNRGGI-UHFFFAOYSA-N
- SMILES
- N1(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C(=O)C(C(O)=O)=C1
- CAS 데이터베이스
- 70458-96-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21/22-36/37/38 | ||
안전지침서 | 26-37/39-24/25 | ||
WGK 독일 | 2 | ||
RTECS 번호 | VB2005000 | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29335990 | ||
유해 물질 데이터 | 70458-96-7(Hazardous Substances Data) | ||
독성 | LD50 in mice, rats (mg/kg): >4000 orally (both species); 1500 s.c. (both species); 470, >500 i.m.; 220, 270 i.v. (Irikura) | ||
기존화학 물질 | KE-13708 |
노르플록사신 C화학적 특성, 용도, 생산
개요
Norfloxacin is the first of the third generation nalidixic acid analogs to reach the marketplace. It exhibits potent in vitro and in vivo activity against Pseudomonas, enteric gram-negative rods and gram-positive cocci. Norfloxacin is orally effective in the treatment of urinary tract infections, including those due to organisms refractory to many other agents.화학적 성질
Off-white to light yellow cryst powder용도
It finds it application as a fluorinated quinolone antibacterial. It is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.정의
ChEBI: A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enz me called DNA gyrase.Antimicrobial activity
It is active against a wide range of Gram-negative bacteria, including Enterobacteriaceae and Campylobacter spp. Ps. aeruginosa, Acinetobacter, Serratia and Providencia spp. are weakly susceptible (and often resistant). It has no useful activity against anaerobes, Chlamydia, Mycoplasma and Mycobacterium spp.Pharmaceutical Applications
A 6-fluoro, 7-piperazinyl quinoline available for oral administration and as an ophthalmic ointment.Pharmacokinetics
Oral absorption: 50–70%Cmax 400 mg oral :1.5 mg/L after 1–1.5 h
Plasma half-life :3–4 h
Volume of distribution: 2.5–3.1 L/kg
Plasma protein binding: 15%
absorption and distribution
Norfloxacin displays linear kinetics. There is no significant accumulation with the recommended dosage of 400 mg every 12 h. Food slightly delays but does not otherwise impair absorption. Antacids reduce absorption. It is widely distributed, but concentrations in tissues other than those of the urinary tract are low: levels in the prostate are around 2.5 mg/g.
Metabolism and excretion
Six or more inactive metabolites are produced. Around 30% of a dose appears as unchanged drug in the urine and <10% as metabolites, producing peak concentrations of microbiologically active drug of around 100–400 mg/L. Urinary recovery is halved by probenecid, with little effect on the plasma concentration. The apparent plasma elimination half-life increases with renal impairment, rising to around 8 h in the anuric patient. Some of the drug appears in the bile where concentrations three- to seven-fold greater than the simultaneous plasma levels are achieved, but this is not a significant route of elimination and hepatic impairment is without effect. Very variable quantities, averaging 30% of a dose, appear in the feces, producing concentrations of active agent of around 200–2000 mg/kg.
Clinical Use
Complicated and uncomplicated urinary tract infections (including prophylaxis in recurrent infections), prostatitisUncomplicated gonorrhea
Gastroenteritis caused by Salmonella, Shigella and Campylobacter spp., Vibrio cholerae
Conjunctivitis (ophthalmic preparation)
부작용
Untoward reactions are those common to the fluoroquinolones. Gastrointestinal tract disturbances, which are generally mild, have been reported in 2–4% of patients. CNS disturbances have largely been limited to headache, drowsiness and dizziness. Co-administration with theophylline results in increased plasma theophylline levels.Safety Profile
Poison by intravenous route.Moderately toxic by other routes. Human systemic effectsby ingestion: musculoskeletal changes. An experimentalteratogen. Other experimental reproductive effects.Mutation data reported. When heated to decomposition itemits노르플록사신 준비 용품 및 원자재
원자재
Pyrazine
P-클로로니트로벤젠
말토덱스트린
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester
무수초산
에톡시메틸렌말론산 디에틸에스테르
경 무기 기름
질산암모늄
3-Chloro-4-fluoroaniline
6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
8-퀴놀린카르복시산
디페닐에테르
피페라진
붕불화수소산
감자전분
에틸브로마이드
아이소아밀 알코올
3,4-디클로로나이트로벤젠
1,2-디클로로벤젠
3-Chloro-4-fluoronitrobenzene
준비 용품
노르플록사신 공급 업체
글로벌( 750)공급 업체
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Zibo Wei Bin Import & Export Trade Co. Ltd. | +86-0533-2091136 +8613864437655 |
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Henan Suikang Pharmaceutical Co.,Ltd. | +8618239973690 |
sales@suikangpharm.com | China | 179 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
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career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
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