디프로필아민

디프로필아민
디프로필아민 구조식 이미지
카스 번호:
142-84-7
한글명:
디프로필아민
동의어(한글):
다이프로필아민;디프로필아민;N-프로필-1-프로판아민;다이-N-프로필아민
상품명:
Dipropylamine
동의어(영문):
DPA;DI-N-PROPYLAMINE;DNPA;n,n-dipropylamine;ai3-24037;(n-C3H7)2NH;Di-n-propyL;DIPROPYLAMINE;Dipropanamine;AURORA KA-7671
CBNumber:
CB1713802
분자식:
C6H15N
포뮬러 무게:
101.19
MOL 파일:
142-84-7.mol
MSDS 파일:
SDS

디프로필아민 속성

녹는점
-63 °C
끓는 점
105-110 °C(lit.)
밀도
0.738 g/mL at 25 °C(lit.)
증기압
38 hPa (20 °C)
굴절률
n20/D 1.4049(lit.)
인화점
39 °F
저장 조건
Store below +30°C.
용해도
35g/l(실험적)
물리적 상태
액체
산도 계수 (pKa)
pK1:10.91(+1) (25°C)
색상
투명한
폭발한계
1.8-9.3%(V)
수용성
녹는
Merck
14,3343
BRN
505974
Dielectric constant
2.9(21℃)
안정성
안정적인. 가연성이 높습니다. 강한 산화제와 호환되지 않습니다.
LogP
1.33 at 23℃
해리상수
11
CAS 데이터베이스
142-84-7(CAS DataBase Reference)
NIST
1-Propanamine, n-propyl-(142-84-7)
EPA
Dipropylamine (142-84-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 F,C
위험 카페고리 넘버 11-20/21/22-35
안전지침서 16-26-36/37/39-45
유엔번호(UN No.) UN 2383 3/PG 2
WGK 독일 1
RTECS 번호 JL9200000
자연 발화 온도 260 °C
TSCA Yes
위험 등급 3
포장분류 II
HS 번호 29211910
유해 물질 데이터 142-84-7(Hazardous Substances Data)
독성 LD50 orally in rats: 0.93 g/kg, H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962)
기존화학 물질 KE-12222
그림문자(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
3
3 0

디프로필아민 C화학적 특성, 용도, 생산

화학적 성질

Dipropylamine, like the other short chain aliphatic amines, is a very strong base, its reactivity being governed by the unshared electron pair on the nitrogen atom. It forms a hydrate with water. The amine also can react with inorganic or organic nitrites under acidic conditions and possibly by reaction with nitrogen oxides from the air to form the highly mutagenic and carcinogenic N-nitrosodipropylamine (ATSDR 1979; Olah et al; Scanlan 1983).

생산 방법

Dipropylamine is manufactured by reaction of propanol and ammonia over a dehydration catalyst at high temperature and pressure (HSDB 1989). Alternatively, propanol and ammonia can be combined with hydrogen over a dehydrogenation catalyst. In each instance, the resulting mixture of primary, secondary, and tertiary amines can be separated by continuous distillation and extraction (Schweizer et al 1978). Dipropylamine is a natural component of vegetables, fish, fruits, and other foods (Mohri 1987) and of tobacco products (WHO 1987). It also is found in human urine (Audunsson 1988), waste water lagoons (Guzewich et al 1983) and in workplace air (Simon and Lemacon 1987).
The toxic compound, N-nitrosodipropylamine, can be produced inadvertently by nitrosation of n-dipropylamine during various manufacturing processes that use the diamine (ATSDR 1989). The nitrosamine, therefore, occurs as an impurity in some dinitroaniline pesticides and rubber products. N-nitrosodipropylamine also is found in various foodstuffs including cheese, cured meats, cooked fish and alcoholic beverages, apparently by reaction of n-dipropylamine with the preservative sodium nitrite (ATSDR 1979; Gross and Newberne 1977; Scanlan 1983).

일반 설명

A clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

공기와 물의 반응

Highly flammable. Soluble in water.

반응 프로필

Dipropylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

건강위험

Inhalation of dipropylamine vapors can result in severe coughing and chest pain due to irritation of airways. Transient symptoms of exposure may include headache, nausea, faintness, and anxiety. Prolonged breathing of vapors may result in lung edema. Dipropylamine also can cause severe irritation and edema of the cornea. A review of the toxicity of dipropylamine has been prepared (Anon 1987).

화재위험

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.

공업 용도

Dipropylamine is used in the rubber industry and as a chemical intermediate in the manufacture of the herbicides S-ethyl-di-n-propylthiocarbamate and S-propyl di-n-propylthiocarbamate (HSDB 1989). Dipropylamine also is employed in the purification of perfluoro compounds to convert the incompletely fluorinated impurities to solids which are then removed by filtration. In 1984, U.S. production was 41 million pounds.

Safety Profile

Poison by ingestion. Moderately toxic by shin contact and inhalation. A skin irritant. A very dangerous fire hazard, when exposed to heat or flame. Can react with oxidizers. Explosion hazard is unknown. Keep away from heat and open flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. See also AMINES

신진 대사

There is little information available on the metabolism and disposition of dipropylamine in biological systems. The available evidence suggests that dipropylamine is not a substrate for monoamine oxidase, but rather is inhibitory. Valiev (1974) administered dipropylamine intraperitoneally to rats and reported it to be moderately inhibitory to liver monoamine oxidase. Previous work by this author demonstrated that lethal doses of dipropylamine and other secondary and tertiary amines significantly inhibited rat liver monoamine oxidase activity (Valiev 1968).
The carcinogenic N-nitrosodipropylamine has been detected in the stomach when dipropylamine (present in fish, vegetables and fruit juices) comes in contact with nitrite, which is often used as a food additive in meats and smoked fish (HSDB 1989). Further metabolism of the carcinogen N-nitrosodipropylamine product formed upon nitrosation of dipropylamine is required to form a highly electrophilic carbonium ion capable of alkylating DNA, etc. (Archer 1981).

디프로필아민 준비 용품 및 원자재

원자재

준비 용품


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