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Ceftizoxime

Ceftizoxime 구조식 이미지
카스 번호:
68401-81-0
상품명:
Ceftizoxime
동의어(영문):
Cefimx;EPOCELIN;FR-13749;Ceftizox;Ceftisomin;CEFTIZOXIME;CEFTIZOXIME ACID;Ceftizoxime (350 mg);Ceftizoxime (350 mg)I0E2620.999mg/mg(an);(6r-(6-alpha,7-beta(z)))-l)(methoxyimino)acetyl)amino)-8-oxo
CBNumber:
CB1717299
분자식:
C13H13N5O5S2
포뮬러 무게:
383.41
MOL 파일:
68401-81-0.mol

Ceftizoxime 속성

녹는점
227° (dec)
밀도
1.89±0.1 g/cm3(Predicted)
산도 계수 (pKa)
pKa 2.1 (Uncertain)
Merck
14,1951
CAS 데이터베이스
68401-81-0(CAS DataBase Reference)

안전

RTECS 번호 XI0367375
HS 번호 2941906000
독성 LD50 intravenous in rat: 8gm/kg

Ceftizoxime C화학적 특성, 용도, 생산

용도

Antibacterial.

정의

ChEBI: A parenteral third-generation cephalosporin, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position.

상표명

Cefizox (Astellas).

Antimicrobial activity

A semisynthetic cephalosporin supplied as the sodium salt. The properties are very similar to those of cefotaxime, but it lacks the acetoxymethyl group at position C-4 and is therefore not subject to deacetylation. Activity against common pathogenic bacteria (Table 13.4) is very similar to that of cefotaxime.
A 500 mg intramuscular injection achieves a plasma concentration of around 14 mg/L. A concentration of 85–90 mg/L is produced 30 min at the end of a 30-min intravenous infusion. The plasma half-life is 1.3–1.9 h. Protein binding is 30%. It is well distributed. In children with meningitis receiving 200–250 mg/kg per day in four equally divided doses for 14–21 days, mean CSF concentrations 2 h after a dose were 6.4 mg/L on day 2 and 3.6 mg/L on day 14.
About 70–90% of the dose is recovered in the urine in the first 24 h, principally by glomerular filtration. Probenecid increases the plasma half-life by about 50%. In patients receiving 1 g intravenously over 30 min, the plasma elimination half-life rose to 35 h when the corrected creatinine clearance was <10 mL/ min. It is partly removed by peritoneal and hemodialysis.
Adverse reactions and clinical use are similar to those of cefotaxime.

Ceftizoxime 준비 용품 및 원자재

원자재

준비 용품


Ceftizoxime 공급 업체

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