Serotonin 5-HT4 receptor (HTR4) gene with five exons spanning ～1.3 Mb, is mapped to human chromosome 5q32. The protein is majorly found in the central nervous system, mainly in limbic structures. HTR4 protein is also expressed in lower levels in various types of tissues including esophagus, ileum, colon, adrenocortical cells, urinary bladder, and heart. HTR4 belongs to the G protein-coupled receptor (GPCR) superfamily. Anti-Serotonin 5-HT4 receptor specifically recognizes human serotonin 5-HT4 receptor.
Biochem/physiol Actions
Serotonin 5-HT4 receptor (HTR4) plays a vital role in psychomotor function and regulation of dopamine secretion. In the central nervous system, HTR4 aids in learning and memory, depression, anxiety, and feeding behavior. HTR4 gene polymorphism leads to the development of asthma, attention-deficit/hyperactivity disorder (ADHD), mood disorders, and schizophrenia.
