PARECOXIB SODIUM
|
|
PARECOXIB SODIUM 속성
- 녹는점
- 273-275°C
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
- 물리적 상태
- 가루
- InChI
- InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
- InChIKey
- OGSQVUBPCQXSGW-UHFFFAOYSA-N
- SMILES
- CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 그림문자(GHS): |
 
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | Danger | |||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
|
|||||||||||||||||||||||||||||||||||
| 예방조치문구: |
|
PARECOXIB SODIUM C화학적 특성, 용도, 생산
개요
Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).화학적 성질
White Solid용도
Anti-inflammatory, analgesic.주요 응용
Parecoxib sodium is a water-soluble sodium salt of the amide prodrug of valdecoxib. Parecoxibundergoes enzymatic hydrolysis in vivo to the active moiety valdecoxib, and is formulated as apowder for solution for parenteral administration. Valdecoxib is a selective inhibitor of the enzymeCOX-2.Biological Functions
A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.PARECOXIB SODIUM 준비 용품 및 원자재
원자재
준비 용품
PARECOXIB SODIUM 공급 업체
글로벌( 395)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 |
CHINA | 964 | 58 | |
| Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |
| Jiangsu Yutian pharmaceutical Co.,Ltd. | +undefined-0518-86098006 +undefined19851887368 |
lvan.hui@jsytsw.com | China | 80 | 58 |
| Hangzhou Benoy Chemical Co., Ltd | +8617342059697 |
sales@benoychem.com | China | 315 | 58 |
| TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD | +86-576-88902229;+86-0576-88902229 +8613968687450 |
yuxin@yuxchem.com | China | 122 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 2259 | 58 |
PARECOXIB SODIUM 관련 검색:
N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyraMide
5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole
Valdecoxib 3'-Sulfonyl Chloride IMpurity
5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL
3-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonaMide
4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole
2-Phenylacetophenone
Valdecoxib IMpurity B
Pantoprazole Sodium
Paliperidone Z-Oxime
4-(3-methyl-4-phenylisoxazol-5-yl)benzenesulfonamide
ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate
5-Methyl-3,4-diphenylisoxazole
DeoxyBenzoinOxime
Valdecoxib 3'-SulfonaMide IMpurity
Parecoxib Impurity H
Parecoxib
Valdecoxib