LUMIRACOXIB
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LUMIRACOXIB 속성
- 녹는점
- 139-141°C
- 끓는 점
- 395.7±42.0 °C(Predicted)
- 밀도
- 1.363±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- ≥29.4 mg/mL in DMSO; insoluble in H2O; ≥27.15 mg/mL in EtOH with ultrasonic
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.18±0.10(Predicted)
- CAS 데이터베이스
- 220991-20-8
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
LUMIRACOXIB C화학적 특성, 용도, 생산
개요
As a second-generation, selective cyclooxygenase (COX-2) inhibitor, lumiracoxib is devoid of the gastrointestinal issues that plague other non-selective, nonsteroidal, anti-inflammatory drugs (NSAIDs) that crossover to COX-1. As an inhibitor of the inducible COX-2 that is up-regulated in pathological processes of pain and inflammation, lumiracoxib blocks the conversion of arachidonic acid to prostaglandins, the mediators of the pathological effects. It’s mode of binding to COX-2 has been found to differ from the other selective COX-2 inhibitors; the carboxylic acid forms hydrogen bonds with Tyr-385 and Ser-530 in the catalytic site rather than seeking interactions within the larger hydrophobic side pocket. Since lumiracoxib is mainly metabolized by CYP2C9, a study evaluating the co-administration of lumiracoxib with fluconazole, a potent inhibitor of CYP2C9, was conducted, and it concluded that there was no need for lumiracoxib dose adjustment, since changes in the systemic exposure were not significant. No serious adverse effects were reported, but in the small number of cases where treatment was discontinued, Gastro intestinal (GI) and musculoskeletal complaints were common.화학적 성질
Pale Yellow Solid용도
Lumiracoxib is a selective cyclooxygenase-2-(COX-2) inhibitor and an anti-inflammatory agent (1,2,3,4).정의
ChEBI: An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthrit s, but was withdrawn due to concersns of hepatotoxicity.LUMIRACOXIB 준비 용품 및 원자재
원자재
준비 용품
LUMIRACOXIB 공급 업체
글로벌( 129)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 |
ramyan@ex-biotech.com | CHINA | 954 | 58 |
| Jurong Coupling Biotechnology Co., Ltd. | 13656108824 |
coupling278191416@hotmail.com | CHINA | 184 | 58 |
LUMIRACOXIB 관련 검색:
인돌 시메티딘
Apremilast
Esomeprazole
ACRYLAMIDE-2,3,3-D3
Isopentyl Pentyl Phthalate
Tributyl phosphate
Rofecoxib
CBPNZQVSJQDFBE-VUWIKSLBSA-N
4-AMINOAZOBENZENE
6-HYDROXYWARFARIN
Dibutyl phosphate
Epi-Lacosamide-d3 (1.0 mg/mL in Acetonitrile)
Tolclofos-methyl
Diflunisal Impurity 1
(2-Fosfomycinyl-1-(hydroxy)propyl)phosphonic Acid
diisopentyl phthalate
SiraMesine, Lu-28-179