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히드록실아파타이트

히드록실아파타이트
히드록실아파타이트 구조식 이미지
카스 번호:
1306-06-5
한글명:
히드록실아파타이트
동의어(한글):
히드록실아파타이트;하이드록시아파타이트;하이드록실아파타이트;히드록실아파타이트(HYDROXYLAPATITE)
상품명:
Hydroxyapatite
동의어(영문):
HA;HAw;monite;BONE ASH;Hydroxya;Bonedust;alveograf;periograf;HA, BOVINE;DURAPATITE
CBNumber:
CB2131094
분자식:
Ca5HO13P3
포뮬러 무게:
502.31
MOL 파일:
1306-06-5.mol

히드록실아파타이트 속성

녹는점
1100 °C(lit.)
저장 조건
−20°C
용해도
H2O: 0.3 mg/mL, clear, colorless
물리적 상태
solid
색상
White
수용성
insoluble H2O [MER06]
Merck
13,3500
CAS 데이터베이스
1306-06-5(CAS DataBase Reference)
EPA
Hydroxylapatite (Ca5(OH)(PO4)3)(1306-06-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 3
RTECS 번호 MY8434000
F 고인화성물질 3-10
TSCA Yes
HS 번호 28352600
유해 물질 데이터 1306-06-5(Hazardous Substances Data)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

히드록실아파타이트 C화학적 특성, 용도, 생산

개요

Calcium hydroxyapatite has a unique structure in that it is conductive along the hydroxide channels. OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) on the c-axis and charge-carrying protons are responsible for the observed conductivities in M10(PO4)6(OH)2. The H+ migration between the electroattractive ion (O2) to give molecular H2O in matrix channels carries charge and the resulting conductivity.
The unit cell consists of two triangular prismatic subcells forming a rhombic prism with vertical sides. There are two horizontal mirror planes at the OH levels of 1/4 and 3/4 of the c-axis. In addition, there is a center of inversion exactly in the center of each vertical face of each subcell.

화학적 성질

Tricalcium phosphate is an odorless and tasteless powder that is stable in air. Tribasic calcium phosphate consists of a variable mixture of calcium phosphates having the approximate composition of 10CaO·3P2O5·H2O.

화학적 성질

white powder

출처

Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.

용도

Prosthetic aid (artificial bone and teeth).

용도

In the 1970s, it was found that sintered calcium hydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated as CaHap), possessed excellent biocompatibility and nontoxicity with femur and mandible bones. Since then, CaHap has been used as a biomaterial for artificial teeth and bones and as a filler for cements and polymers. Today, bone fillers made of CaHap are widely used in the medical and dental fields. In the 1980s, it was found that sintered CaHap has a good compatibility with skin tissues. Hence, percutaneous devices based on CaHap have been developed and applications have included continuous ambulatory peritoneal dialysis and intravenous hyperalimentation systems, blood pressure measurement and blood access for nutrition. Recently, many researchers have studied the chemistry of apatites, particularly CaHap, and have found various applications, such as artificial teeth and bones, ion exchangers, adsorbents for chromatography to separate proteins and enzymes, catalysts, ionic conductors, temperature and gas sensors, etc.

제조 방법

The technical product is also known as “bone ash.” Commercial preparation from phosphate rock.

정의

The major constituent of bone and tooth mineral. It is finely divided, crystalline, nonstoichiometric material rich in surface ions (carbonate, magnesium, citrate), which are readily replaced by fluoride ion, thus affording protection to the teeth.

상표명

Alveograf (Sterling Winthrop); Periograf (Sterling Winthrop).

Pharmaceutical Applications

Modified hydroxylapatite, also frequently called hydroxyapatite and better known as bone mineral, makes up ~50% of our bones. Hydroxylapatite is a natural form of the mineral calcium apatite, whose formula is usually denoted as Ca10(PO4)6(OH)2. Modifications of hydroxylapatite can also be found in the teeth, and a chemically identical substance is often used as filler for replacement of bones, and so on. Nevertheless, despite similar or identical chemical compositions, the response of the body to these compounds can be quite different.

히드록실아파타이트 준비 용품 및 원자재

원자재

준비 용품


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