(4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT 속성
저장 조건
-20°C
용해도
DMSO：18mg/mL，60℃
물리적 상태
고체
물리적 상태
단단한 모양
색상
회백색
안전
WGK 독일
3
(4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT C화학적 특성, 용도, 생산
용도
AH23848 has been used as an prostaglandin E2 receptor 4 (EP4) receptor antagonist to study its effect on cAMP accumulation in monocrotaline (MCT28d) rat pulmonary arterial smooth muscle cells (PASMCs) and human T cell enriched peripheral blood mononuclear cells (PBMC). It has also been used to study its effect on the expressions of collagen-I, metalloproteinase (MMP-1), MMP-3, and EP4 gene expression in human tendon fibroblasts following interleukin (IL)-1β treatment.
Biochem/physiol Actions
AH23848 regulates nitric oxide (NO) production and reduces endogenous cAMP accumulation. This is carried out by declination of inducible nitric oxide synthase (iNOS) gene expression and acceleration of iNOS protein degradation in glomerular mesangial cells.
(4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT 준비 용품 및 원자재
원자재
준비 용품
(4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT 공급 업체
