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Octreotide acetate

Octreotide acetate 구조식 이미지
카스 번호:
83150-76-9
상품명:
Octreotide acetate
동의어(영문):
ctreotide;DARAMONOL;OXTREOTIDE;Longastatin;Octreotode Acetate;Octreotide acetate;Ocetreotide, Acetate;APIOC OCTREOTIDE ACETATE;Octreotide Hydrochloride;OCTREOTIDE ACETATE (GMP)
CBNumber:
CB2138033
분자식:
C49H66N10O10S2
포뮬러 무게:
1019.24
MOL 파일:
83150-76-9.mol

Octreotide acetate 속성

저장 조건
−20°C
용해도
H2O: soluble
InChIKey
DEQANNDTNATYII-MEUDYGGUSA-N
CAS 데이터베이스
83150-76-9

안전

WGK 독일 3

Octreotide acetate C화학적 특성, 용도, 생산

개요

Octreotide is a long-acting somatostatin analog indicated for symptomatic control in acromegaly and gastroenteropancreatic tumors. Other potential uses under investigation include diabetes, psoriasis and Alzheimer's disease.

Originator

Sandoz (Switzerland)

용도

Antisecretory (gastric).

Indications

Octreotide acetate (Sandostatin) is a synthetic peptide analogue of the hormone somatostatin. Its actions include inhibition of the pituitary secretion of growth hormone and an inhibition of pancreatic islet cell secretion of insulin and glucagon. Unlike somatostatin, which has a plasma half-life of a few minutes, octreotide has a plasma elimination half-life of 1 to 2 hours. Excretion of the drug is primarily renal.

상표명

Sandostatin (Novartis).

Veterinary Drugs and Treatments

Octreotide may be useful in the adjunctive treatment of hyperinsulinemia in patients with insulinomas (especially dogs, ferrets). Response is variable, presumably dependent on whether the tumor cells have receptors for somatostatin. Octreotide may also be useful in the diagnosis and symptomatic treatment of gastrinomas in dogs or cats. It may be of use in the treatment of acute pancreatitis, but more research is needed before it can be recommended for this use in veterinary patients.

효소 저해제

This orally bioavailable octapeptide somatostatin analogue (FW = 1019.24 g/mol; CAS 83150-76-9; 79517-01-4 (acetate salt); 135467-16-2 (pamoate salt); D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-NH-CH (CH2OH) CHOHCH3), also known as SMS 201-995 and Sandostatin®, is a long-lasting and more potent inhibitor of growth hormone, glucagon, and insulin than is somatostatin. Its synthesis was enabled by stepwise modification of a conformationally stabilized analogue of the fragment of somatostatin that had been thought to be a biologically active moiety. Indeed, octreotide displaces [3H[naloxone from its binding sites (IC50 = 38 nM), or >200x more potent than somatostatin. As measured by the difference between the binding of [3H]-dihydromorphine, [3H]-[D-Ala2,D-Leu5]enkephalin, and (–) -[3H]-bremazocine, SMS 201-995 appears to be highly specific for the opiate μ binding site. Octreotide immediate-release injection is used to decrease the amount of growth hormone produced in acromegaly

Octreotide acetate 준비 용품 및 원자재

원자재

준비 용품


Octreotide acetate 공급 업체

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