Uridine-5'-diphosphate disodium salt
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Uridine-5'-diphosphate disodium salt 속성
- 저장 조건
- -20°C
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 물에 약간 용해됩니다.
- 감도
- Moisture Sensitive
- BRN
- 8817400
- InChIKey
- KWDGQJWFEYTPBN-IBOJMDDDSA-L
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r|
- CAS 데이터베이스
- 27821-45-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Uridine-5'-diphosphate disodium salt C화학적 특성, 용도, 생산
용도
Uridine-5'-diphosphate disodium salt (UDP-Na2) is an organometallic compound, It is a P2Y6 receptor agonist and GPR105 receptor inhibitor. It is used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled Protein Receptors (GPCR) and cell signaling molecules such as Rho-signaling via Guanine Nucleotide Exchange Factors (GEF).주요 응용
Uridine 5′-diphosphate disodium salt hydrate has been used:as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina
Purification Methods
Crystallise it from MeOH. It may contain some Ba salt(s); hence stir it with Amberlite IR-120 cation exchanger (25mL, wet resin, 15-50 mesh in H+ form) in H2O (50mL) until the nucleotide dissolves. Filter, wash resin with H2O until the eluate is neutral. Combine the filtrate and washings, and adjust the pH to 8.0 with 2.0 M aqueous NaOH. Concentrate it in vacuo to a small volume (~ 20mL), and add Me2CO dropwise until crystallisation begins. Cool to 0o, and the shiny plates of di Na uridine-5’-phosphate dihydrate are filtered off and dried over P2O5 at 25o/0.1mm for 24hours (>76% recovery). UV: max at 262nm ( 10,000 M-1cm -1) in 0.1 M HCl. [Boon et al. J Chem Soc 408 1950, Smith Biochemical Preparations 8 130 1960.] [Beilstein 24 IV 1214.]Uridine-5'-diphosphate disodium salt 준비 용품 및 원자재
원자재
준비 용품
Uridine-5'-diphosphate disodium salt 공급 업체
글로벌( 337)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
Hangzhou Weitai Biological Pharmaceutical Co.,Ltd. | +8613282012786 |
sales@weitai-pharmaceutical.com | China | 61 | 58 |
Hebei Duling International Trade Co. LTD | +8618032673083 |
sales05@hbduling.cn | China | 15745 | 58 |
HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18112526015 |
sales@runyanpharma.com | China | 326 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 |
sales@zhswyy.com | China | 338 | 58 |
Hangzhou Meiya Pharmaceutical Co Ltd | +86-021-33686691 +8618001850931 |
sales@meiyapharm.com | China | 57 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Uridine-5'-diphosphate disodium salt 관련 검색:
우리딘 에틸렌디아민테트라아세트산, 이나트륨 염 인산 나트륨, 이염기
Pamidronate disodium salt
Doxifluridine
1-beta-D-Arabinofuranosyluracil
Clodronate disodium
UDP
Sodium Monofluorophosphate
Uridine-5'-triphosphoric acid trisodium salt
Uridine 5′-monophosphate disodium salt
UMP
URODILATIN HUMAN
Uridine Diphosphate Choline
Diquafosol
UDP-rhamnose
uridine 5'-diphosphoglucose disodium salt from saccharomyces cerevisiae,Uridine 5'-diphosphoglucose disodium salt
Guanosine-5'-diphosphate disodium salt