고급 알코올 황산에스테르염

고급 알코올 황산에스테르염
고급 알코올 황산에스테르염 구조식 이미지
카스 번호:
151-21-3
한글명:
고급 알코올 황산에스테르염
동의어(한글):
N-도데킬술페이트나트륨;도데킬황산염,나트륨염;황산나트륨N-도데킬;황산나트륨라우릴;황산라우릴나트륨;황산모노도데킬나트륨;고급알코올황산에스테르염;도데실황산나트륨;라우릴술페이트나트륨;라우릴황산나트륨;알킬황산염;황산나트륨도세실;나트륨메톡시드;소듐메틸레이트;나트륨메틸레이트;펠달라트NM;나트륨메탄산화물;소듐라우릴설페이트;도데실황산나트륨;설퓨릭산 모노도데실에스테르 나트륨 염
상품명:
Sodium dodecyl sulfate
동의어(영문):
SDS;SDS;SDS;SLES;sls;SODIUM LAURYL SULPHATE;SODIUM DODECYL SULPHATE;LAURYL SODIUM SULFATE;Rutile Sand;DODECYL SULFATE SODIUM SALT
CBNumber:
CB2147453
분자식:
C12H25NaO4S
포뮬러 무게:
288.38
MOL 파일:
151-21-3.mol

고급 알코올 황산에스테르염 속성

녹는점
204-207 °C (lit.)
밀도
1.03 g/mL at 20 °C
FEMA
4437 | SODIUM LAURYL SULFATE
인화점
>100°C
저장 조건
2-8°C
용해도
H2O: 0.1 M, clear to nearly clear, colorless to slightly yellow
물리적 상태
Powder or Crystals
색상
White to pale yellow
냄새
Slight fatty odour
pH 범위
7.2
수소이온지수(pH)
6-9 (10g/l, H2O, 20℃)
수용성
ca. 150 g/L (20 ºC)
최대 파장(λmax)
λ: 260 nm Amax: 0.3
λ: 280 nm Amax: 0.2
Merck
14,8636
BRN
3599286
InChIKey
DBMJMQXJHONAFJ-UHFFFAOYSA-M
CAS 데이터베이스
151-21-3(CAS DataBase Reference)
EPA
Sodium lauryl sulfate (151-21-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 F,Xn,Xi
위험 카페고리 넘버 36/37/38-36/38-22-11-21/22-42-41-20/21/22-37/38
안전지침서 26-36/37-36/37/39-36-22-39
유엔번호(UN No.) UN 2926 4.1/PG 2
WGK 독일 2
RTECS 번호 WT1050000
F 고인화성물질 3
TSCA Yes
위험 등급 4.1
포장분류 III
HS 번호 29209010
유해 물질 데이터 151-21-3(Hazardous Substances Data)
독성 LD50 orally in rats: 1288 mg/kg (Walker)
기존화학 물질 KE-21884
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
3
3 1

고급 알코올 황산에스테르염 MSDS


Lauryl sulfate sodium salt

고급 알코올 황산에스테르염 C화학적 특성, 용도, 생산

화학적 성질

White crystalline flakes

용도

Sodium dodecyl sulfate is an emulsifier and whipping aid that has a solubility of 1 g in 10 ml of water. It functions as an emulsifier in egg whites. It is used as a whipping aid in marshmallows and angel food cake mix. It also functions to aid in dissolving fumaric acid.

생산 방법

Sodium lauryl sulfate is prepared by sulfation of lauryl alcohol, followed by neutralization with sodium carbonate.

정의

An anionic surfactant, usually a mixture of sodium alkyl sulfates that lowers surface tension of aqueous solutions.

일반 설명

White to pale yellow paste or liquid with a mild odor. Sinks and mixes with water.

공기와 물의 반응

Insoluble in water.

반응 프로필

DODECYL SULFATE is incompatible with strong oxidizers. Sodium dodecyl sulfate is also incompatible with cationic materials and with acids with pH below 2.5. Salts, basic, such as DODECYL SULFATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

건강위험

Inhalation of dust causes sneezing and coughing. Ingestion of large amounts causes irritation of stomach. Dust irritates eyes and may cause burns on prolonged contact. Contact with skin causes some irritation; continued exposure to water solution causes drying out and cracking.

화재위험

Flash point data for Sodium dodecyl sulfate are not available; however, Sodium dodecyl sulfate is probably combustible.

Pharmaceutical Applications

Sodium lauryl sulfate is an anionic surfactant employed in a wide range of nonparenteral pharmaceutical formulations and cosmetics.
It is a detergent and wetting agent effective in both alkaline and acidic conditions. In recent years it has found application in analytical electrophoretic techniques: SDS (sodium dodecyl sulfate) polyacrylamide gel electrophoresis is one of the more widely used techniques for the analysis of proteins; and sodium lauryl sulfate has been used to enhance the selectivity of micellar electrokinetic chromatography (MEKC).

색상 색인 번호

This anionic detergent is widely used in cosmetics and industry. As a skin irritant agent, SLS can be used in several dermatological applications. It is also a good indicator of excited skin during patch testing.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. A human skin irritant. An experimental eye and severe skin irritant. A mild allergen. Mutation data reported. When heated to decomposition it emits toxic fumes of SO, and Na2O. See also ESTERS and SULFATES.

Safety

Sodium lauryl sulfate is widely used in cosmetics and oral and topical pharmaceutical formulations. It is a moderately toxic material with acute toxic effects including irritation to the skin, eyes, mucous membranes, upper respiratory tract, and stomach. Repeated, prolonged exposure to dilute solutions may cause drying and cracking of the skin; contact dermatitis may develop.(3) Prolonged inhalation of sodium lauryl sulfate will damage the lungs. Pulmonary sensitization is possible, resulting in hyperactive airway dysfunction and pulmonary allergy. Animal studies have shown intravenous administration to cause marked toxic effects to the lung, kidney, and liver. Mutagenic testing in bacterial systems has proved negative.
Adverse reactions to sodium lauryl sulfate in cosmetics and pharmaceutical formulations mainly concern reports of irritation to the skin or eyes following topical application.
Sodium lauryl sulfate should not be used in intravenous preparations for humans. The probable human lethal oral dose is 0.5–5.0 g/kg body-weight.
LD50 (mouse, IP): 0.25 g/kg
LD50 (mouse, IV): 0.12 g/kg
LD50 (rat, oral): 1.29 g/kg
LD50 (rat, IP): 0.21 g/kg
LD50 (rat, IV): 0.12 g/kg

저장

Sodium lauryl sulfate is stable under normal storage conditions. However, in solution, under extreme conditions, i.e. pH 2.5 or below, it undergoes hydrolysis to lauryl alcohol and sodium bisulfate.
The bulk material should be stored in a well-closed container away from strong oxidizing agents in a cool, dry place.

Purification Methods

Purify this detergent by Soxhlet extraction with pet ether for 24hours, followed by dissolution in acetone/MeOH/H2O 90:5:5(v/v) and recrystallisation [Politi et al. J Phys Chem 89 2345 1985]. It has been purified by two recrystallisations from absolute EtOH, aqueous 95% EtOH, MeOH, isopropanol or a 1:1 mixture of EtOH/isopropanol to remove dodecanol, and dried under vacuum [Ramesh & Labes J Am Chem Soc 109 3228 1987]. SDS has also been purified by repeatedly foaming whereby a 0.15% aqueous solution is made to foam and the foam is discarded, then the H2O is removed in vacuo and the residue is diluted to the required concentrations [see Cockbain & McMullen Trans Faraday Soc 47 322 1951] or by liquid-liquid extraction [see Harrold J Colloid Sci 15 280 1960]. Dry it over silica gel. For DNA work it should be dissolved in excess MeOH passed through an activated charcoal column and evaporated until it crystallises out. It has also been purified by dissolving in hot 95% EtOH (14mL/g), filtering and cooling, then drying in a vacuum desiccator. Alternatively, it is crystallised from H2O, vacuum dried, washed with anhydrous Et2O and dried in vacuum again. These operations are repeated five times [Maritato J Phys Chem 89 1341 1985, Lennox and McClelland J Am Chem Soc 108 3771 1986, Dressik J Am Chem Soc 108 7567 1986]. [Beilstein 1 IV 1847.]

비 호환성

Sodium lauryl sulfate reacts with cationic surfactants, causing loss of activity even in concentrations too low to cause precipitation. Unlike soaps, it is compatible with dilute acids and calcium and magnesium ions.
Sodium lauryl sulfate is incompatible with salts of polyvalent metal ions, such as aluminum, lead, tin or zinc, and precipitates with potassium salts. Solutions of sodium lauryl sulfate (pH 9.5–10.0) are mildly corrosive to mild steel, copper, brass, bronze, and aluminum.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (dental preparations; oral capsules, suspensions, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

고급 알코올 황산에스테르염 준비 용품 및 원자재

원자재

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