하이드로퀴논모노벤질에터
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하이드로퀴논모노벤질에터 속성
- 녹는점
- 119-120 °C (lit.)
- 끓는 점
- 297.96°C (rough estimate)
- 밀도
- 1,26 g/cm3
- 굴절률
- 1.5906 (estimate)
- 저장 조건
- Store below +30°C.
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 10.29±0.15(Predicted)
- 물리적 상태
- 분말, 결정 및/또는 덩어리
- 색상
- 미색부터 베이지, 브라운까지
- 수용성
- 약간 용해됨
- Merck
- 14,6248
- BRN
- 1958305
- InChIKey
- VYQNWZOUAUKGHI-UHFFFAOYSA-N
- LogP
- 2.651 (est)
- CAS 데이터베이스
- 103-16-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36-43 | ||
안전지침서 | 24/25-26-37 | ||
WGK 독일 | 2 | ||
RTECS 번호 | SJ7700000 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29095090 | ||
유해 물질 데이터 | 103-16-2(Hazardous Substances Data) | ||
독성 | LD50 i.p. in mice: >600 mg/kg (Takahashi) |
하이드로퀴논모노벤질에터 C화학적 특성, 용도, 생산
개요
4-(Benzyloxy)phenol, also called monobenzone and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water.The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans.
화학적 성질
4-Benzyloxyphenol is a cream to beige-light brownish crystals classified as a hydroquinone monobenzyl ether. It is soluble in alcohol, benzene and ether, and almost insoluble in water. 4-Benzyloxyphenol is a depigmenting agent that has the effect of enhancing the rate of elimination of melanin secreted by skin cells, and studies have shown that the molecular mechanism of its action may be related to tyrosinase.용도
4-Benzyloxyphenol is used in the synthesis of bis(4-benzyloxyphenoxy)phenyl phosphine oxide. It plays an essential role in the preparation of hetaryl-azophenol dyes via heterocyclic amines in nitrosyl sulphuric acid. It is also used for polyester fiber dyeing and in rubber industry. It acts as a depigmenting agent.Indications
Monobenzone (Benoquin) potently inhibits melanin production and destroys melanocytes. Like hydroquinone, monobenzone was originally introduced for the topical treatment of disorders of excess melanin pigmentation, including melasma. It is now used only to permanently depigment the remaining normally pigmented skin in patients with extensive vitiligo. Irritant and allergic contact dermatitis are common side effects.정의
ChEBI: Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a melanin synthesis inhibitor, a dermatologic drug and an allergen. It derives from a hydroquinone.제조 방법
4-Benzyloxyphenol Synthesis: Add 2.63g (0.028mol) of hydroquinone to a 100mL conical flask, weigh 1.12g (0.028mol) of sodium hydroxide, add 8mL of water, wait for the sodium hydroxide to dissolve and add dropwise to the conical flask with hydroquinone, shake well, then add 15mL of DMF and 2.52g (0.02mol) of benzyl chloride, under microwave radiation power of 320W The reaction was cooled to room temperature at the end of the reaction. The reaction was first adjusted to alkalinity with 10% sodium hydroxide, filtered, and the filtrate was washed with 10% sodium hydroxide until the filtrate was colorless (the filtrate was hydroquinone bis(benzyl ether), which could be recycled). The filtrate was acidified with hydrochloric acid to make Monobenzone completely precipitated, and then washed by filtration and ice water, recrystallized with alcohol and water, and decolorized by activated carbon to obtain 2.55g of white solid, the yield was 63.79%.부작용
Side effects:Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Intense itching, blistering, burning, or swelling of the skin.
Mild skin rash, tenderness, or redness.
Purification Methods
Crystallise it from EtOH or H2O, and dry (P2O5) under vacuum. [Walter et al. J Am Chem Soc 108 5210 1986, Beilstein 6 IV 5778.]하이드로퀴논모노벤질에터 준비 용품 및 원자재
원자재
준비 용품
하이드로퀴논모노벤질에터 공급 업체
글로벌( 638)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
Hubei Aumei New Material Co., Ltd. | +86-027-87366298 +8615927270571 |
tianyi@skbiology.cn | China | 294 | 58 |
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD | 15202951039 |
jason@sgonekbio.com | China | 268 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 153 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Beri Pharma Co., Ltd. | +8613417710166 |
sales@zhberi.com | China | 227 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5866 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
Nanjing Deda New Material Technology Co., Ltd | +8613223293093 |
bella@njdeda.com | China | 80 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 905 | 58 |
하이드로퀴논모노벤질에터 관련 검색:
탄게레틴 바이칼레인 6-히드록시플라바논 디벤질에테르 6-히드록시플라본 시넨세틴
SCUTELLAREIN TETRAMETHYL ETHER
Monobenzone
6-METHOXYLUTEOLIN
6-METHOXYFLAVONE
4-BENZYLOXYPHENOXYACETIC ACID
3',4',5',5,6,7-HEXAMETHOXYFLAVONE
3,3',4',5,6,7-HEXAHYDROXYFLAVONE
1,4-Dibenzyloxybenzene
6-METHOXYFLAVONOL
ESCULETIN DIBENZYL ETHER
3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE