디아이오딘하이드록시퀴놀린
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디아이오딘하이드록시퀴놀린 속성
- 녹는점
- >200 °C (dec.) (lit.)
- 끓는 점
- 370.95°C (rough estimate)
- 밀도
- 2.3013 (estimate)
- 저장 조건
- Refrigerator
- 용해도
- DMSO(소량으로 용해, 난방), 에틸아세테이트(소량으로 용해, 난방)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- pKa 8.0 (Uncertain)
- 색상
- 옅은 노란색에서 밝은 베이지색까지
- 수용성
- 1g/L at 26℃
- Merck
- 14,5042
- InChIKey
- UXZFQZANDVDGMM-UHFFFAOYSA-N
- LogP
- 0.602 at 26℃
- CAS 데이터베이스
- 83-73-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-41 | ||
| 안전지침서 | 26-36/37/39 | ||
| 유엔번호(UN No.) | 3249 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | VC5775000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29334900 | ||
| 유해 물질 데이터 | 83-73-8(Hazardous Substances Data) | ||
| 독성 | LD50 intravenous in mouse: 56mg/kg |
| 그림문자(GHS): |
 
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| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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디아이오딘하이드록시퀴놀린 C화학적 특성, 용도, 생산
Indications
Iodoquinol (diiodohydroxyquin, Yodoxin, Moebiquin) is a halogenated 8-hydroxyquinoline derivative whose precise mechanism of action is not known but is thought to involve an inactivation of essential parasite enzymes. Iodoquinol kills the trophozoite forms of E. histolytica, B. coli, B. hominis, and Dientamoeba fragilis.Iodoquinol is absorbed from the gastrointestinal tract and is excreted in the urine as glucuronide and sulfate conjugates. Most of an orally administered dose is excreted in the feces. Iodoquinol has a plasma half-life of about 12 hours.
Iodoquinol is the drug of choice in the treatment of asymptomatic amebiasis and D. fragilis infections. It is also used in combination with other drugs in the treatment of other forms of amebiasis and as an alternative to tetracycline in the treatment of balantidiasis.
Adverse reactions are related to the iodine content of the drug; the toxicity is often expressed as skin reactions, thyroid enlargement, and interference with thyroid function studies. Headache and diarrhea also occur. Chronic use of clioquinol, a closely related agent, has been linked to a myelitislike illness and to optic atrophy with permanent loss of vision.
Clinical Use
5,7-Diiodo-8-quinolinol, 5,7-diiodo-8-hydroxyquinoline,or diiodohydroxyquin (Yodoxin, Diodoquin, Diquinol) is ayellowish to tan microcrystalline, light-sensitive substancethat is insoluble in water. It is recommended for acute andchronic intestinal amebiasis but is not effective in extraintestinaldisease. Because a relatively high incidence of topicneuropathy has occurred with its use, iodoquinol should notbe used routinely for traveler’s diarrhea.Safety Profile
Poison by ingestion and intravenous routes. Human systemic effects by ingestion: eye effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Iand NoxPurification Methods
It crystallises from xylene and is dried at 70o in a vacuum. [Beilstein 21 II 58.]디아이오딘하이드록시퀴놀린 준비 용품 및 원자재
원자재
8-하이드록시퀴놀린
요오드산 칼륨
요오드화 칼륨
살리실산
1,2-Benzenedicarboxylic acid, 1-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] ester
[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate
메트론이드아졸
물
프탈 산
요오드 모노염화물(베타)
염산
숙신산
준비 용품
디아이오딘하이드록시퀴놀린 공급 업체
글로벌( 226)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 2263 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |