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W-7 HYDROCHLORIDE

W-7 HYDROCHLORIDE 구조식 이미지

카스 번호:: 61714-27-0

상품명:: W-7 HYDROCHLORIDE

동의어(영문):: W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL;6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium

CBNumber:: CB2182197

분자식:: C16H22Cl2N2O2S

포뮬러 무게:: 377.33

MOL 파일:: 61714-27-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 127

W-7 HYDROCHLORIDE 속성

녹는점: 220-222 °C

저장 조건: -20°C

용해도: 메탄올: 25 mg/mL, 투명, 무색

물리적 상태: 회백색 결정질 고체

색상: 흰색에서 황백색까지

BRN: 6030174

CAS 데이터베이스: 61714-27-0(CAS DataBase Reference)

안전

위험품 표기	Xi
안전지침서	22-24/25
WGK 독일	3
RTECS 번호	QK0786000
F 고인화성물질	3-10
HS 번호	2935909099

W-7 HYDROCHLORIDE C화학적 특성, 용도, 생산

개요

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (K_i = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (K_i = 70 and 300 μM, respectively).

화학적 성질

White Crystalline Solid

용도

W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

일반 설명

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 μM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 μM).

생물학적 활성

Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

W-7 HYDROCHLORIDE 준비 용품 및 원자재

원자재

준비 용품

W-7 HYDROCHLORIDE 공급 업체

글로벌( 127)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

W-7 HYDROCHLORIDE 관련 검색:

1-클로로나프탈렌 헥사메틸렌디아민 디염화수소산염 부틸벤젠술폰아미드 W-7 HYDROCHLORIDE (+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE 1,2,5,6-TETRAHYDRO-1-METHYL-NICOTINIC ACID HYDROCHLORIDE 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE 1-(2,4-DICHLOROPHENYL)HYDRAZINE HYDROCHLORIDE -EthylbenzenesulfonaMide [+/-]-1-[2,5-DIMETHOXYPHENYL]-2-GLYCINAMIDOETHANOL HYDROCHLORIDE 1-(2,4-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,3-DIMETHYLPHENYL)PIPERAZINE HYDROCHLORIDE 10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz[b,f]azepine hydrochloride 1-(2,6-DICHLOROPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,4-DIFLUOROPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,5-DIMETHOXYBENZYL)PIPERAZINE HYDROCHLORIDE W-5 HYDROCHLORIDE 1-(2,5-DIFLUOROPHENYL)BIGUANIDE HYDROCHLORIDE