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Meloxicam

Meloxicam 구조식 이미지
카스 번호:
71125-38-7
상품명:
Meloxicam
동의어(영문):
MOBIC;MOBEC;Coxicam;METACAM;CH83850;Mobicox;Movalis;Movatec;Parocin;eloxicam
CBNumber:
CB2191355
분자식:
C14H13N3O4S2
포뮬러 무게:
351.4
MOL 파일:
71125-38-7.mol

Meloxicam 속성

녹는점
255 °C
밀도
1.613±0.06 g/cm3(Predicted)
저장 조건
0-6°C
용해도
DMSO: soluble
물리적 상태
Off-white solid
산도 계수 (pKa)
4.08 in water; 4.24 ± 0.01 in water/ethanol (1:1); 4.63 ± 0.03 in water/ethanol (1:4)
색상
yellow
수용성
Soluble in water (22 mg/ml), DMSO (25 mg/ml), DMF, acetone(slightly soluble), ethanol(slightly soluble), and methanol(slightly soluble).
Merck
14,5826
안정성
Stable. Incompatible with strong oxidizing agents.
InChIKey
ZRVUJXDFFKFLMG-UHFFFAOYSA-N
EPA
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-, 1,1-dioxide (71125-38-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T
위험 카페고리 넘버 22-36/37/38-25
안전지침서 26-45-60-36/37
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 3
RTECS 번호 DL0702000
위험 등급 6.1
포장분류 III
HS 번호 29349990
독성 LD50 orally in mice: 470 mg/kg (Trummlitz, 1980)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

Meloxicam MSDS


Meloxicam

Meloxicam C화학적 특성, 용도, 생산

개요

Mobec was launched in Columbia, Denmark, France, Germany, Ireland, Italy, Netherlands, S. Africa, Sweden, and the UK for osteo- and rheumatoid arthritis as an NSAID. It can be synthesized in four steps from benzisothiazolo-3(2H)-one- 1,1-dioxide. By shutting down prostaglandin synthesis, it has antiinflammatory, antipyretic and analgesic properties. This is accomplished by preferentially inhibiting the COX-2 system relative to the COX-I which also leads to an improved GI safety profile relative to naproxen, diclofenac and prioxicam. It can also interfere with neutrophil function like degranulation. Meloxicam did not inhibit proteoglycan synthesis in osteroarthitic cartilage or chondrocytes and had no effect on platelet aggregation. It is metabolized by the P450 2C9 system into four metabolites which are all inactive.

개요

Viramune was launched in the US for use in combination with nucleoside analogs to treat HIV-infected adults who have experienced clinical and/or immulogic deterioration. It can be prepared in four steps from 2chloro-4-methyl-3-nitropyridine. It is a potent inhibitor of HIV-1 reverse transcriptase with no rnuscarinic or benzodiazepine activity. Mechanistically, it is a non-competitive non-nucleoside inhibitor. It has a low toxicity for uninfected cells most likely due to its specificity, i.e., it does not inhibit eukaryotic DNA polymerase α, β, γ and δ. HIV-2, SIV and FeLV are not affected by nevirapine and monotherapy is limited by the rapid onset of resistance.

화학적 성질

Light Yellow Solid

Originator

Boehringer Ingelheim (Germany)

Originator

Boehringer lngelheim (Germany)

용도

Preferential cyclooxygenase (COX-2) inhibitor. Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.

용도

angiotensin 2 receptor antagonist

용도

For symptomatic treatment of arthritis and osteoarthritis.

용도

An inhibitor of Cox-1 and Cox-2, selective for Cox-2.

용도

Preferential cyclooxygenase (COX-2) inhibitor. Used as an anti-inflammatory.

정의

ChEBI: A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.

Indications

Meloxicam (Mobic), recently introduced for the treatment of osteoarthritis, is also used for rheumatoid arthritis and certain acute conditions. Although meloxicam is sometimes reported to be a selective COX-2 inhibitor, it is considerably less selective than celecoxib or rofecoxib. Its adverse effects are similar to those of piroxicam and other NSAIDs; however, the frequency of GI side effects is lower for meloxicam than for piroxicam and several other NSAIDs.

상표명

Mobic (Boehringer Ingelheim).

일반 설명

Meloxicam (Mobic) is a selective COX-2 inhibitor amongoxicams indicated for use in RA and OA. It also has a relativelylong half-life of 15 to 20 hours and has a much lowerrate of serious GI side effects and a lower than average riskof nephropathy when compared with other conventionalNSAIDs.196 The recommended dose is 7.5 mg once dailywith a maximum of 15 mg/d. Meloxicam is metabolized inhumans mainly by CYP2C9 (with a minor contribution viaCYP3A4) to 5'-hydroxymethylmeloxicam and 5 carboxymeloxicam.
In large-scale comparative trials, meloxicam was foundto be at least as effective as most conventional NSAIDs inthe treatment of rheumatic disease or postoperative pain, buthas demonstrated a more favorable GI tolerability profile.

Veterinary Drugs and Treatments

Meloxicam is principally used for the symptomatic treatment of osteoarthritis in dogs. Short-term (single dose injectable) use is also approved (in the USA) for cats for the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration when administered prior to surgery.

Meloxicam 준비 용품 및 원자재

원자재

준비 용품


Meloxicam 공급 업체

글로벌( 367)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
+86-531-58897093 394876348@qq.com CHINA 150 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 913 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3015 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24687 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30054 58
Hebei Huanhao Biotechnology Co., Ltd.
86-18034554576 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 721 58

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