β-에스트라디올
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β-에스트라디올 속성
- 녹는점
- 178-179 °C(lit.)
- 알파
- D25 +76 to +83° (dioxane)
- 끓는 점
- 355.44°C (rough estimate)
- 밀도
- 1.0708 (rough estimate)
- 굴절률
- 80.4 ° (C=1, Dioxane)
- 인화점
- 2℃
- 저장 조건
- room temp
- 용해도
- 물에 거의 녹지 않고, 아세톤에 녹고, 에탄올(96%)에 조금 녹고, 염화메틸렌에 약간 녹습니다.
- 산도 계수 (pKa)
- pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 디메틸 설폭사이드, 에탄올, 물, 인산염 완충 식염수, 디메틸 포름아미드, 아세톤, 디옥산 및 알칼리 수산화물에 용해됩니다. 식물성 기름에 약간 용해됩니다.
- Merck
- 14,3703
- BRN
- 1914275
- BCS Class
- 1
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- VOXZDWNPVJITMN-ZBRFXRBCSA-N
- CAS 데이터베이스
- 50-28-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn,F | ||
---|---|---|---|
위험 카페고리 넘버 | 60-61-45-63-64-40-36-20/21/22-11-48 | ||
안전지침서 | 53-22-36/37/39-45-36/37-26-16-36-20 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | KG2975000 | ||
F 고인화성물질 | 8-10 | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29372390 | ||
유해 물질 데이터 | 50-28-2(Hazardous Substances Data) | ||
독성 | LD50 subcutaneous in rat: > 300mg/kg |
β-에스트라디올 C화학적 특성, 용도, 생산
화학적 성질
White or almost white, crystalline powder or colourless crystals.용도
17β-Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.정의
ChEBI: The 17beta-isomer of estradiol.주요 응용
β-Estradiol has been used:for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
as a supplement in in vitro maturation medium (IVM), which is used as a control medium
in estrogen-induction assay
원료
Estradiol is the most potent endogenous estrogen, exhibiting high affinity for the ER and high potency when administered parenterally. When administered orally, estradiol is promptly conjugated in the intestine and oxidatively metabolized by the liver, resulting in its low oral bioavailability and therapeutic effectiveness.일반 설명
Estradiol, estra-1,3,5(10)-triene-3,17β-diol, is the most activeof the natural steroid estrogens. Although its 17β-OHgroup is vulnerable to bacterial and enzymatic oxidation toestrone, it can be temporarily protected as anester at C3 or C17, or permanently protected by adding a17α-alkyl group (e.g., 17α-ethinyl estradiol, the most commonlyused estrogen in oral contraceptives). The increasedoil solubility of the 17β-esters (relative to estradiol) permitsthe esters to remain in oil at the IM injection site for extendedperiods. These derivatives illustrate the principles of steroidmodification. Transdermal estradiolproducts avoid first-pass metabolism, allowing estradiol tobe as effective as oral estrogens for treating menopausalsymptoms. A new transdermal spray, Evamist, was approvedin 2007. Estradiol itself is typically not very effective orallybecause of rapid metabolism, but an oral formulation of micronizedestradiol that allows more rapid absorption of thedrug is available (Estrace). In addition to the oral and transdermalproducts, estradiol is also available in gel, cream, andvaginal ring formulations. The commercially available estradiolesters are the following:Estradiol 3-acetate, USP (oral; vaginal ring)
Estradiol 17-valerate, USP (IM injection)
Estradiol 17-cypionate, USP (IM injection).
위험도
A carcinogen (OSHA).생물학적 활성
Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.색상 색인 번호
Natural estradiol, used in transdermal systems for hormonal substitution, can induce allergic contact dermatitis, with the risk of systemic contact dermatitis after oral reintroduction.Mechanism of action
The most potent naturally occurring estrogen in mammals. It is synthesized primarily in the ovary, and also in the testis, adrenal gland and placenta, and to a limited extent by peripheral tissues (e.g., liver, fat, and skeletal muscle) from androstenedione and testosterone. It is responsible for the development of secondary sex characteristics in the female at puberty (i.e., growth and development of the vagina, uterus and fallopian tubes, enlargement of the breasts, and growth and maturation of long bones).Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A promoter. Human reproductive effects by ingestion: ferthty effects. Experimental reproductive effects. Human mutation data reported. A steroid hormone much used in medicine. When heated to decomposition it emits acrid smoke and irritating fumes.잠재적 노출
The working environment may be contaminated during sex hormone manufacture, especially during the extraction and purification of natural steroid hormones; grinding of raw materials; handling of powdered products and recrystallization. Airborne particles of sex hormones may be absorbed through the skin, ingested or inhaled. Enteric absorption results in quick inactivation of sex hormones in the liver. The rate of inactivation is decreased for the oral, alkylated steroid hormones (methyl testosterone, anabolic steroids, etc.). Sex hormones may accumulate and reach relatively high levels even if their absorption is intermittent. Consequently, repeated absorption of small amounts may be detrimental to health. Intoxication by sex hormones may occur in almost all the exposed workers if preventive measures are not taken. The effect in the industrial sector is more successful than the agricultural one (chemical caponizing of cockerels by stilbestrol implants and incorporation of estrogens in feed for body weight gain promotion in beef cattle), where measures taken are summary and the number of cases of intoxication is consequently bigger운송 방법
UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materialsPurification Methods
17-Estradiol (previously known as -estradiol) is purified by chromatography on SiO2 (toluene/EtOAc 4:1) and recrystallised from CHCl3/hexane or 80% EtOH. It is stable in air, is insoluble in H2O, and is precipitated by digitonin. The UV has max at 225 and 280 nm. The diacetate [3434-88-6] has m 97-98o and forms leaflets from aqueous EtOH. The 3-benzoate crystallises from aqueous MeOH withm 193o and [] D 25 +58o to 63o (c 1, dioxane). [Meischer & Scholz Helv Chim Acta 20 263, 1237 1937, Biochem J 32 1273 1938, Oppolzer & Roberts Helv Chim Acta 63 1703 1980, Inhoffen & Zühlsdorff Chem Ber 7 4 1914 1941, Beilstein 6 IV 6611.]β-에스트라디올 준비 용품 및 원자재
원자재
P-톨루엔설폰 산
ADD
3# ketone
질소
비페닐
디페닐메탄
에스트론
Dibromo
Acetylacetone
칼륨보로하이드라이드
4-ETHYL-2-METHYLPYRIDINE
리튬
준비 용품
β-에스트라디올 공급 업체
글로벌( 730)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 |
ada@sh-teruiop.com | China | 892 | 58 |
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 |
nutrabiotech@outlook.com | China | 300 | 58 |
Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 |
market02@senwayer.com | China | 874 | 58 |
Zhuzhou New Peptides Tech Co.,Ltd. | +8618073326374 |
sales@goodpeptides.com | China | 140 | 58 |
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1532 | 58 |
CONTIDE BIOTECH CO.,LTD | +85253358525 |
xena@healthtide-api.com | China | 525 | 58 |
Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 |
xinhao-6@xinhaoshengwu.com | China | 350 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 |
Ethan@dornechem.com | China | 293 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
β-에스트라디올 관련 검색:
에스트리올 히드로코르티손 17-베타-에스트라디올 벤조산 이노시톨 장미 벵갈 나트륨 에티닐에스트라디올 메스트라놀 β-에스트라디올
Motolimod
ESTRADIOL, 17B-,CIS-ESTRADIOL,B-ESTRADIOL,BETA-ESTRADIOL
BETA-ESTRADIOL 17-VALERATE
Estradiol Cypionate
BETA-ESTRADIOL-17-ENANTHATE
ESTRIOL TRISULFATE TRISODIUM SALT
Quinestrol
2-HYDROXYESTRADIOL
BETA-ESTRADIOL 3-METHYL ETHER
ESTRIOL TRIACETATE