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Fimasartan

Fimasartan 구조식 이미지

카스 번호:: 247257-48-3

상품명:: Fimasartan

동의어(영문):: Kanarb;BR-A-657;Fimasartan;Fimasartan D4;Unii-p58222188p;KANARB; BR-A-657;Fimasartan(BR-A-657);FiMasartan USP/EP/BP;Fimasartan Impurity H;2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim

CBNumber:: CB22128722

분자식:: C27H31N7OS

포뮬러 무게:: 501.65

MOL 파일:: 247257-48-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 173

Fimasartan 속성

녹는점: >155°C (dec.)

끓는 점: 693.0±65.0 °C(Predicted)

밀도: 1.25

저장 조건: 2-8°C

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 4.16±0.10(Predicted)

색상: 흰색에서 황백색까지

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Fimasartan C화학적 특성, 용도, 생산

개요

Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the brand name Kanarb by Boryung Pharmaceuticals.

용도

Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.

생물학적 활성

Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

Mechanism of action

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.

Fimasartan 준비 용품 및 원자재

원자재

2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide

준비 용품

Fimasartan 공급 업체

글로벌( 173)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Zhuhai Hairuide Bioscience and Technology Co., Ltd	+8618928027945	sales3@zhhairuide.com	China	97	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Zibo Wei Bin Import & Export Trade Co. Ltd.	+86-0533-2091136 +8613864437655	ziboweibinmaoyi@163.com	China	100	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Fimasartan 관련 검색:

터트-뷰틸클로로다이메틸실란 아크릴산메틸 디시오 옥사마이드 메틸파라벤 쿠레톡심메틸 아세트산 메틸 벤설프론 메틸 티오판산-메틸 브롬화 메틸 메틸 파라싸이온(메틸 파라티온) (S)-Indacaterol 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide Pyrazine METSULFURON METHYL N-(n-Butyl)thiophosphoric triamide Methyl 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole METHYL TRIPHENYLMETHYL ETHER