mouse,LD50,intraperitoneal,2500mg/kg (2500mg/kg),Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 229, Pg. 1011, 1976.
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H226
인화성 액체 및 증기
인화성 액체
구분 3
경고
H315
피부에 자극을 일으킴
피부부식성 또는 자극성물질
구분 2
경고
P264, P280, P302+P352, P321,P332+P313, P362
H319
눈에 심한 자극을 일으킴
심한 눈 손상 또는 자극성 물질
구분 2A
경고
P264, P280, P305+P351+P338,P337+P313P
H335
호흡 자극성을 일으킬 수 있음
특정 표적장기 독성 - 1회 노출;호흡기계 자극
구분 3
경고
예방조치문구:
P210
열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P302+P352
피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
(2-MERCAPTOETHYL)TRIMETHYLSILANE C화학적 특성, 용도, 생산
물리적 성질
bp 144–146 °C [52–54 °C (25 Torr)]; d 0.850.
용도
2-(Trimethylsilyl)ethanethiol is a reagent used as a monoprotected sulfide dianion equivalent for
the two-step installation of a divalent sulfur atom into organic molecules. It participates in the reactions of Thiol Substitution Reactions, Source of Sulfur Acid Derivatives, etc.
제조 방법
The high commercial cost of
2-(trimethylsilyl)ethanethiol necessitates methods for its
lab scale synthesis. The radical addition of thiolacetic acid to
vinyltrimethylsilane occurs thermally to afford a 9:1 ratio of
regioisomers, the 1- and 2-(trimethylsilyl)ethyl thiolesters of
acetic acid (eq 1). Photochemical initiation may improve the
ratio of regioisomers obtained. Purification of the thiolacetate
by careful fractional distillation should be performed prior
to conversion to the thiol in order to ensure high purity. The
conversion to thiol is best performed with LAH3 or methanolic
K2CO3, but ammonolysis may also be suitable. Saponification
with KOH in water/ethanol is slightly less efficient.
Direct radical addition of liquid H2S to vinyl trimethylsilane
has been demonstrated, but the procedure is low-yielding and inconvenient.
