글루타이미드
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글루타이미드 속성
- 녹는점
- 155-157 °C (lit.)
- 끓는 점
- 211.82°C (rough estimate)
- 밀도
- 1.2416 (rough estimate)
- 굴절률
- 1.4200 (estimate)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- soluble in Chloroform, DCM
- 물리적 상태
- 결정 또는 결정질 플레이크
- 산도 계수 (pKa)
- pKa 11.4 (Uncertain)
- 색상
- 하얀색
- 수용성
- 물, 뜨거운 에탄올 및 끓는 벤젠에 용해됩니다. 에테르에 불용성.
- BRN
- 110052
- InChI
- InChI=1S/C5H7NO2/c7-4-2-1-3-5(8)6-4/h1-3H2,(H,6,7,8)
- InChIKey
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N
- SMILES
- N1C(=O)CCCC1=O
- CAS 데이터베이스
- 1121-89-7(CAS DataBase Reference)
글루타이미드 C화학적 특성, 용도, 생산
화학적 성질
white crystalline powder용도
Glutarimide acts as an inhibitor of protein synthesis. Further, it is used as a reactant for thionations and biocatalytic asymmetric synthesis of sitagliptin production. It is also employed in the generation of beta-adrenoceptor ligands, enantioselective synthesis of securinega alkaloids and alfa-fluoro-alfa amino amides. In addition to this, it is used in intramolecular amidocyclopropanation reactions.제조 방법
To a flask containing 70 gm (0.53 mole) of glutaric acid is added 150 ml (2.2 mole) of 28% aqueous ammonia. The mixture is set for distillation and heated for 7 hr as the temperature of the mixture rises from 90° to 180°C. The temperature is held at 170-180°C for \\ hr or until the evolution of ammonia ceases. The reaction mixture solidifies on cooling and the product is recrystallized from acetone to afford 37.4 gm (63%), m.p. 145-146°C.t may be advantageous to preform the ammonium salt of dicarboxylic acids prior to the application of enough heat to form the imide. The preparation of succinimide is a case in point.
정의
ChEBI: A dicarboximide that is piperidine which is substituted by oxo groups at positions 2 and 6.일반 설명
A glutarimide antibiotic, 9-methylstreptimidone, shows antiviral, antitumor and antifungal activities.Purification Methods
Purify it by dissolving 75g in 200mL of H2O, boil for 30minutes with 2g of charcoal, filter, evaporate to dryness and recystallise the residue from 125mL of 95% EtOH to give 70g of white crystals, m 152-154o. It also crystallises from Me2CO (m 163-165o) or EtOH (m 153-154o). The N-bromo derivative (a brominating agent) crystallises from H2O with m 180-185o. [Paris et al. Org Synth Coll Vol IV 496 1963, Beilstein 21 H 382, 21 I 331, 21 II 307, 21 III/IV 4582.]글루타이미드 준비 용품 및 원자재
원자재
준비 용품
글루타이미드 공급 업체
글로벌( 218)공급 업체
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| Accela ChemBio Inc. | (+1)-858-699-3322 |
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sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |