SERTINDOLE
|
|
SERTINDOLE 속성
- 녹는점
- 95-100°C
- 끓는 점
- 592.1±50.0 °C(Predicted)
- 밀도
- 1.36
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- DMSO: >10mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 14.53±0.20(Predicted)
- 색상
- 회백색
- Merck
- 14,8466
- InChIKey
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
SERTINDOLE C화학적 특성, 용도, 생산
개요
Serdolect was launched in the UK for acute and chronic schizophrenia and schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l- (4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain and has a high affinity for the serotinin 5-HT2 receptor where it behaves as an antagonist. It has weak affinity for the α1-adrenergic receptor and no affinity for dopamine D2 receptors. It is as effective as haloperidol but without the extrapyramidal symptoms. This may be a consequence of the fact that it expresses the c-fos protein in a manner different for haloperidol but similar to clozapine. It is non-sedating, long lasting (several days after a single dose) and has an atypical mode of action.화학적 성질
Off-White to Pale Yellow Solid용도
Antipsychotic used in the treatment of schizophrenia.정의
ChEBI: A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-o oimidazolidin-1-yl)ethyl group.부작용
Sertindole is an indole-containing compound that behaves as a high-affinity serotonin 5-HT2 receptor antagonist, with weak affinity for adrenergic α1 receptors and almost no affinity for dopaminergic D2 receptors. It is about as effective as haloperidol in the treatment of acute and chronic schizophrenia, but with much lower incidence of extrapyramidal side effects. Sertindole is relatively nonsedating, and its effects are long lasting (several days).SERTINDOLE 준비 용품 및 원자재
원자재
5-CHLORO-1-(4-FLUORO-PHENYL)-3-(1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE
1-(2-Chloroethyl)imidazolidin-2-one
5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE
5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE
4-oxopiperidinium chloride
준비 용품
SERTINDOLE 공급 업체
글로벌( 132)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 |
info@rochipharma.com | China | 431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 |
mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
SERTINDOLE 관련 검색:
Penfluridol
CHEMBRDG-BB 4013121
5-CHLORO-1-METHYLINDOLE
5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE
1-(4-FLUOROPHENYL)PYRROLE
5-CHLORO-3-(1-METHYL-4-PIPERIDINYL)INDOLE
N-(PIPERIDINOETHYL)ETHYLENEDIAMINE
5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE
3-Piperidin-4-yl-1H-indole
3-(1-METHYL-4-PIPERIDINYL)INDOLE
SERTINDOLE
1-(2-AMINOETHYL)-2-IMIDAZOLIDONE