장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴
특정 표적장기 독성 - 반복 노출
구분 1
위험
P260, P264, P270, P314, P501
H411
장기적 영향에 의해 수생생물에 유독함
수생 환경유해성 물질 - 만성
구분 2
예방조치문구:
P273
환경으로 배출하지 마시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
9,13b-디하이드록시-1H-디벤즈[c,f]이미다조[1,5-a]아제핀-3-아민 (CAS No. 80012-43-7) C화학적 특성, 용도, 생산
개요
Epinastine hydrochloride, an orally active antihistaminic agent, was marketed in
Japan for the treatment of bronchial asthma, allergic rhinitis, urticaria, eczema,
dermatitis, and psoriasis vulgaris.Epinastine is one of the most effective
peripherally acting histamine H1-receptor antagonists without sedative effects.In
addition, it exhibits potent anti-PAF and anti-LT activity which may also contribute
significantly to its antiallergic activity. Chronic epinastine has been reported to
effectively inhibit airway hyper-responsiveness in rats. Potent inhibitory effects of
epinastine on bronchoconstriction induced by histamine and bradykinin, but not by
other chemical mediators, has also been reported. Studies have indicated that there
are no significant differences in pharmacological properties among D-, L-, and
racemic epinastine.
용도
Epinastine is antihistamine and mast cell stabilize that is used in eye drops for the treatment of allergic conjunctivitis.
정의
ChEBI: A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Clinical Use
Epinastine is a potent, long-acting H1 antihistamine and an inhibitor of the release of
histamine and other transmitters from mast cells. It has some affinity for H2 receptors as well.
It is used as an eye drop for allergic conjunctivitis. It does not penetrate into the CNS and is
classified as a nonsedating antihistamine.
9,13b-디하이드록시-1H-디벤즈[c,f]이미다조[1,5-a]아제핀-3-아민 (CAS No. 80012-43-7) 준비 용품 및 원자재
![9,13b-디하이드록시-1H-디벤즈[c,f]이미다조[1,5-a]아제핀-3-아민 (CAS No. 80012-43-7)](CAS/GIF/80012-43-7.gif)
